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null Sergio Burgos, PhD

Investigator, RI-MUHC

Metabolic Disorders and Complications Program

Centre for Translational Biology

Associate Professor, Department of Animal Science, Faculty of Agricultural and Environmental Sciences, McGill University

 

Keywords

nutrition • metabolism • insulin resistance • skeletal muscle

Research Focus

Research in my laboratory focuses on understanding how diet influences insulin sensitivity in humans. Insulin promotes glucose storage in adipose, muscle and liver. A reduced sensitivity of target tissues to insulin is a harbinger of type 2 diabetes. Diet is a major modifiable factor that influences the development of this disease. My laboratory conducts metabolic and clinical studies to characterize the effect of dietary components on insulin sensitivity. Our goal is to develop dietary strategies that delay or prevent the development of type 2 diabetes.

Selected Publications

Click on Pubmed to see my current publications list

  • Dai M, Yan G, Wang N, Daliah G, Edick AM, Poulet S, Boudreault J, Ali S, Burgos SA, Lebrun JJ. In vivo genome-wide CRISPR screen reveals breast cancer vulnerabilities and synergistic mTOR/Hippo targeted combination therapy. Nat Commun. 2021 May 24;12(1):3055. doi: 10.1038/s41467-021-23316-4. PMID: 34031411.

  • Dai M, Boudreault J, Wang N, Poulet S, Daliah G, Yan G, Moamer A, Burgos SA, Sabri S, Ali S, Lebrun JJ. Differential Regulation of Cancer Progression by CDK4/6 Plays a Central Role in DNA Replication and Repair Pathways. Cancer Res. 2021 Mar 1;81(5):1332-1346. doi: 10.1158/0008-5472.CAN-20-2121. Epub 2020 Dec 28. PMID: 33372040.

  • Auclair O, Burgos SA. Protein consumption in Canadian habitual diets: usual intake, inadequacy, and the contribution of animal- and plant-based foods to nutrient intakes. Appl Physiol Nutr Metab. 2021 May;46(5):501-510. doi: 10.1139/apnm-2020-0760. Epub 2020 Nov 20. PMID: 33216633.

  • Edick AM, Auclair O, Burgos SA. Role of Grb10 in mTORC1-dependent regulation of insulin signaling and action in human skeletal muscle cells. Am J Physiol Endocrinol Metab. 2020 Feb 1;318(2):E173-E183. doi: 10.1152/ajpendo.00025.2019. Epub 2019 Dec 3. PMID: 31794259.

  • Burgos SA, Chevalier S, Morais JA, Lamarche M, Kellett S, Marliss EB. Acute hyperaminoacidemia does not suppress insulin-mediated glucose turnover in healthy young men. Appl Physiol Nutr Metab. 2021 Apr;46(4):397-403. doi: 10.1139/apnm-2020-0495. Epub 2020 Oct 20. PMID: 33080141.