Breadcrumb

null Steven Paraskevas, MD, PhD

Senior Scientist, RI-MUHC, Glen site

Metabolic Disorders and Complications Program

Centre for Translational Biology

Professor, Department of Surgery, Faculty of Medicine and Health Sciences, McGill University

Department of Surgery, Division of Adult General Surgery, MUHC

 

Keywords

transplantation • islet • antigen presentation • stem cells • immunity

Research Focus

My research focuses on signals released by transplanted grafts that provide a key stimulus to the immune system. I am also involved in a large research group developing a stem-cell based device to reverse diabetes.

Selected Publications

Click on Pubmed to see my current publications list

  • Fouda, S Negi, O Zaremba, R Gaidar, S Paraskevas, J Tchervenkov, Discovery, synthesis, and in vitro characterization of 2,3 derivatives of 4,5,6,7-tetrahydro-benzthiophene as potent modulators of retinoic acid receptor-related orphan receptor γt, J Med Chem, 2023, Jun 8;66(11): 7355-73. doi: 10.1021/acs.jmedchem.3c00021. PMID: 37172324.

  • AK Rutman, S Negi, N Saberi, K Khan, JI Tchervenkov, S Paraskevas, Extracellular vesicles from kidney allografts express miR-218-5p and alter Th17/Treg ratios, Front Immunol, 2022, Feb 23; 13: article 784374. PMID: 35281056.

  • AK Rutman, S Negi, M Gasparrini, *CP Hasilo, J Tchervenkov and S Paraskevas, Immune response to extracellular vesicles from human islets of Langerhans in patients with Type 1 diabetes, Endocrinology, 2018 Nov 1;159(11):3834-3847. PMID: 30307543.

  • SA Fernandez, L Danielczak, G Gauvin-Rossignol, C Hasilo, A Bégin-Drolet, J Ruel, S Paraskevas, RL Leask, CA Hoesli, An in vitro perfused macroencapsulation device to study hemocompatibility and survival of islet-like cell clusters, Front Bioeng Biotechnol, 2021, May 28;9:674125. PMID: 34124024.

  • TB McGregor, A Sener, K Yetzer, C Gillrie, S Paraskevas, The impact of COVID-19 on the Canadian Kidney Paired Donation program: an opportunity for universal implementation of kidney shipping. Can J Surg, 2020 Oct 01; 63(5): E451-3. doi: 10.1503/cjs.012620.