null Terence Coderre, M.Sc., PhD
pain • nociception • analgesia • neuroplasticity • excitatory amino acids
My research focuses on the transition from acute to chronic pain with particular attention to plasticity in spinal cord neurons in relation to neuropathic pain, inflammatory pain and complex regional pain syndrome (CRPS).
Fulas OA, Laferriere A, Stein RS, Bohle DS, Coderre TJ. Topical combination of meldonium and N-acetyl cysteine relieves allodynia in rat models of CRPS-1 and peripheral neuropathic pain by enhancing NO-mediated tissue oxygenation. J Neurochem 2020; 152:570-584.
*George NC, Laferriere A, Coderre TJ. Sex differences in the contributions of spinal atypical PKCs and downstream targets to the maintenance of nociceptive sensitization. Mol Pain 2019; 15:1744806919840582.
Vincent K*, Wang SF*, Laferriere A, Kumar N, Coderre TJ. Spinal intracellular metabotropic glutamate receptor 5 (mGluR5) contributes to pain and c-fos expression in a rat model of inflammatory pain. Pain 2017, 158:705-716.
Ragavendran JV, Laferrière A, Bennett GJ, Ware MA, Gandhi W, Bley K, Schweinhardt P, Coderre TJ. Effects of topical combinations of clonidine and pentoxifylline on capsaicin-induced allodynia and post-capsaicin tourniquet-induced pain in healthy volunteers: a double-blind, randomized, controlled study. Pain 2016, 157:2366-2374.
Vincent K*, Cornea V, Jong Y-JI, Laferriere A, Kumar N, Mickeviciute A*, Fung ST*, Bandegi P*, Ribeiro-da-Silva A, O’Malley K, Coderre TJ. Intracellular mGluR5 plays a critical role in neuropathic pain. Nature Commun 2016, 7:10604.