Tomoko Takano, MD, PhD - Research Institute of the McGill University Health Centre
nephrotic syndrome • proteinuria • podocytes • Rho-GTPases • cytoskeleton
My research focuses on how the barrier function of the kidney is maintained and how proteinuria (leakage of protein in urine) contributes to the progression of kidney failure. When the kidney makes urine, it retains important proteins in the blood and eliminates waste products in the urine. When this barrier function is impaired in the kidney, proteins start to leak into the urine (proteinuria). Proteinuria is often the first manifestation of a kidney disease and the more proteinuria a patient has, the more likely they are to develop kidney failure. A particular emphasis is on the function of the cell called "podocytes", which play critical role in the kidney barrier. By stopping proteinuria, we hope to arrest the progression of kidney failure.
ARHGDIA: a novel gene implicated in nephrotic syndrome. Gupta IR, Baldwin C, Auguste D, Ha KC, El Andalousi J, Fahiminiya S, Bitzan M, Bernard C, Akbari MR, Narod SA, Rosenblatt DS, Majewski J, Takano T. J Med Genet. 2013;50(5), 330-8. PMID: 23434736.
Nuclear factor of activated T cells mediates RhoA-induced fibronectin upregulation in glomerular podocytes. Zhu L, Qi XY, Aoudjit L, Mouawad F, Baldwin C, Nattel S, Takano T. Am J Physiol Renal Physiol. 2013;304(7):F849-62. PMID: 23389455.
Podocyte Protein, Nephrin, Is a Substrate of Protein Tyrosine Phosphatase 1B. Aoudjit L, Jiang R, Lee TH, New LA, Jones N, Takano T. J Signal Transduct. 2011;2011:376543. PMID: 22013520.
Activation of RhoA in podocytes induces focal segmental glomerulosclerosis. Zhu L, Jiang R, Aoudjit L, Jones N, Takano T. J Am Soc Nephrol. 2011;22(9):1621-30. PMID: 21804090.
Complement-mediated activation of calcium-independent phospholipase A2γ: role of protein kinases and phosphorylation. Elimam H, Papillon J, Takano T, Cybulsky AV. J Biol Chem. 2013;288(6):3871-85. PMID: 23258543.