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Skeletal muscle • resistance and endurance exercise • protein and amino acid metabolism • stable isotope tracers • nutrition and muscle health • aging
My research focuses on skeletal muscle protein metabolism and how it is regulated in response to nutrition and physical (in)activity. I am particularly interested in the mechanisms of skeletal muscle loss in humans, which occurs with aging and muscle disuse, and identifying optimal lifestyle interventions focused on exercise and nutritional approaches to protect and restore skeletal muscle mass and strength across the lifespan. My research incorporates stable isotope tracer methods to obtain dynamic measures of muscle protein turnover (i.e., protein synthesis and breakdown) in-vivo in humans. Some of my more recent research has focused on the impact of different sources of dietary protein on myofibrillar and mitochondrial protein synthesis rates following a session of concurrent resistance- and endurance-type exercise. The ultimate aim of my research program is to contribute to improving the overall health, well-being, and physical functioning of our society.
Smiles WJ, Churchward-Venne TA, van Loon LJC, Hawley JA, Camera DM. A single bout of strenuous exercise overcomes lipid-induced anabolic resistance to protein ingestion in overweight, middle-aged men. FASEB J. 2019 Mar 6:fj201801917R. doi: 10.1096/fj.201801917R. [Epub ahead of print]. PMID: 30840513.
Churchward-Venne TA, Pinckaers PJM, Smeets JSJ, Peeters WM, Zorenc AH, Schierbeek H, Rollo I, Verdijk LB, van Loon LJC. Myofibrillar and Mitochondrial Protein Synthesis Rates Do Not Differ in Young Men Following the Ingestion of Carbohydrate with Whey, Soy, or Leucine-Enriched Soy Protein after Concurrent Resistance- and Endurance-Type Exercise. J Nutr. 2019 Jan 29. doi: 10.1093/jn/nxy251. [Epub ahead of print]. PMID: 30698812.
Churchward-Venne TA, Pinckaers PJM, Smeets JSJ, Peeters WM, Zorenc AH, Schierbeek H, Rollo I, Verdijk LB, van Loon LJC. Myofibrillar and Mitochondrial Protein Synthesis Rates Do Not Differ in Young Men Following the Ingestion of Carbohydrate with Milk Protein, Whey, or Micellar Casein after Concurrent Resistance- and Endurance-Type Exercise. J Nutr. 2019 Jan 29. doi: 10.1093/jn/nxy244. [Epub ahead of print]. PMID: 30698725.
Moore DR, Kelly RP, Devries MC, Churchward-Venne TA, Phillips SM, Parise G, Johnston AP. Low-load resistance exercise during inactivity is associated with greater fibre area and satellite cell expression in older skeletal muscle. J Cachexia Sarcopenia Muscle. 2018 Aug;9(4):747-754. doi: 10.1002/jcsm.12306. Epub 2018 May 14. PMID: 29761654.
Murphy CH, Shankaran M, Churchward-Venne TA, Mitchell CJ, Kolar NM, Burke LM, Hawley JA, Kassis A, Karagounis LG, Li K, King C, Hellerstein M, Phillips SM. Effect of resistance training and protein intake pattern on myofibrillar protein synthesis and proteome kinetics in older men in energy restriction. J Physiol. 2018 Jun;596(11):2091-2120. doi: 10.1113/JP275246. Epub 2018 Apr 17. PMID: 29532476.