RI-MUHC Annual Report





Lifespan perspective on congenital heart disease research

Dr. Ariane Marelli led a project to operationalize emerging concepts through the presentation of new constructs in congenital heart disease (CHD) research. These concepts include long-term trajectories and a life course epidemiology framework. The study proposed an evolving framework that integrates genetic, phenotypical, and environmental factors that influence the natural history and clinical course of patients with CHD across the lifespan. (Journal of the American College of Cardiology)

Accurately assessing risk for preeclampsia

In a prospective longitudinal study, Dr. Stella Daskalopoulou and her team assessed vascular parameters in women with singleton high-risk pregnancies. Results demonstrate the potential clinical utility of two parameters, arterial stiffness and wave reflection, to be used together as an early screening tool for preeclampsia. This study may aid in development of appropriate clinical monitoring strategies and effective therapeutic interventions in high-risk pregnancies. (Metabolism)

Protective effect for heart failure events in patients hospitalized with COVID-19

Dr. Abhinav Sharma led the RAAS-COVID-19 trial to evaluate whether continuation versus discontinuation of renin-angiotensin aldosterone system inhibitors (RAASi) were associated with short-term clinical or biochemical outcomes in patients hospitalized with COVID-19. The researchers found that RAASi continuation in these patients appears safe, whereas discontinuation increased brain natriuretic peptide levels and may increase risk of acute heart failure. The trial concluded that, where possible, RAASi therapy should be continued. (American Heart Journal)

Drs. Ariane Marelli, Stella Daskalopoulou and Abhinav Sharma (L to R)
Drs. Ariane Marelli, Stella Daskalopoulou and Abhinav Sharma (L to R)

Selected CHAL Program news links



Kashif Khan, Christophe Caron, Ibtisam Mahmoud, Ida Derish, Adel Giaid, Renzo Cecere. Extracellular Vesicles as a Cell-free Therapy for Cardiac Repair: a Systematic Review and Meta-analysis of Randomized Controlled Preclinical Trials in Animal Myocardial Infarction Models: Stem Cell Reviews and Reports, 2022. doi: 10.1007/s12015-021-10289-6.

Kim Phan, Ian Schiller, Nandini Dendukuri, Y. H. Gomez, Jessica Gorgui, Amira El-Messidi, Robert Gagnon, Stella S. Daskalopoulou. A longitudinal analysis of arterial stiffness and wave reflection in preeclampsia: Identification of changepoints: Metabolism: Clinical and Experimental 120, 2021. doi: 10.1016/j.metabol.2021.154794.

Marco M. Ochs, Isabelle Kajzar, Janek Salatzki, Andreas T. Ochs, Johannes H. Riffel, Nael F. Osman, Hugo Albert Katus, Matthias G. Friedrich. Hyperventilation/Breath-Hold Maneuver to Detect Myocardial Ischemia by Strain-Encoded CMR: Diagnostic Accuracy of a Needle-Free Stress Protocol: JACC: Cardiovascular Imaging 14(10): 1932-1944, 2021. doi: 10.1016/j.jcmg.2021.02.022.

Hong Y. Choi, Isabelle L. Ruel, Jacques Genest. Identification of Docetaxel as a Potential Drug to Promote HDL Biogenesis: Frontiers in Pharmacology 12, 2021. doi: 10.3389/fphar.2021.679456.

Gerhard Paul Diller, Alexandra Arvanitaki, Alexander R. Opotowsky, Kathy J. Jenkins, Philip Moons, Aleksander Kempny, Animesh (Aashoo) Tandon, Andrew N. Redington, Paul Khairy Dr, Seema R. Mital, Michael Gatzoulis, Yue Li, Ariane J. Marelli. Lifespan Perspective on Congenital Heart Disease Research: JACC State-of-the-Art Review: Journal of the American College of Cardiology 77(17): 2219-2235, 2021. doi: 10.1016/j.jacc.2021.03.012.

Luiz Fernando Ybarra, Nicoló Piazza. Expanding the Role of Coronary Computed Tomography Angiography in Interventional Cardiology: Circulation 145(1): 5-7, 2022. doi: 10.1161/CIRCULATIONAHA.121.053038.

Valeria Raparelli, Marcella Nunez Smith, Hassan Behlouli, Terrence E. Murphy, Gail D’Onofrio, Louise Pilote, Rachel P. Dreyer. Impact of race on the in-hospital quality of care among young adults with acute myocardial infarction: Journal of the American Heart Association 10(17), 2021. doi: 10.1161/JAHA.121.021408.

Faizan Khan, Tobias Tritschler, Susan R. Kahn, Marc Alan Rodger. Venous thromboembolism: The Lancet 398(10294): 64-77, 2021. doi: 10.1016/S0140-6736(20)32658-1.

Abhinav Sharma, Yinggan Zheng, Justin A. Ezekowitz, Cynthia M. Westerhout, Jacob A. Udell, Shaun G. Goodman, Paul W. Armstrong, John B. Buse, Jennifer B. Green, Robert G. Josse, Keith D. Kaufman, Darren K. McGuire, Giuseppe Ambrosio, Lee Ming Chuang, Rena. Cluster Analysis of Cardiovascular Phenotypes in Patients With Type 2 Diabetes and Established Atherosclerotic Cardiovascular Disease: A Potential Approach to Precision Medicine: Diabetes Care 45(1): 204-212, 2022. doi: 10.2337/dc20-2806.

Allan David Sniderman, Tamara Glavinovic, George Thanassoulis. Key Questions About Familial Hypercholesterolemia: JACC Review Topic of the Week: Journal of the American College of Cardiology 79(10): 1023-1031, 2022. doi: 10.1016/j.jacc.2022.01.010.

Robert Goulden, Brian H. Rowe, Michal Abrahamowicz, Erin C. Strumpf, Robyn M. Tamblyn. Association of Intravenous Radiocontrast with Kidney Function: A Regression Discontinuity Analysis: JAMA Internal Medicine 181(6): 767-774, 2021. doi: 10.1001/jamainternmed.2021.0916.

Philip Greenland, Erin D. Michos, Nicole Redmond, Lawrence J. Fine, Karen P. Alexander, Walter T. Ambrosius, Kirsten B. Bibbins-Domingo, Michael J. Blaha, Ron Blankstein, Stephen P. Fortmann, Amit Khera, Donald M. Lloyd-Jones, David J. Maron, James Min, J. Brent Muhlestein, Khurram Nasir, Madeline R. Sterling, George Thanassoulis. Primary Prevention Trial Designs Using Coronary Imaging: A National Heart, Lung, and Blood Institute Workshop: JACC: Cardiovascular Imaging 14(7): 1454-1465, 2021. doi: 10.1016/j.jcmg.2020.06.042.

Ninian Lang, Rhian M. Touyz. Mechanistic science in cardiovascular-oncology: the way forward to maximise anti-cancer drug effects and minimise cardiovascular toxicity: Clinical Science 135(23): 2661-2663, 2021. doi: 10.1042/CS20210986.





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