Researcher from The Institute co-leads $8.3 million genomics sequencing project to advance healthcare for Black communities
SOURCE: The Research Institute of the McGill University Health Centre (The Institute)
March 14, 2025
Loydie Jerome-Majewska, PhD, a senior scientist at the Research Institute of the McGill University Health Centre (The Institute), is one of four research co-leaders awarded $8.3 million by Genome Canada for a groundbreaking project in precision medicine. As part of the newly launched Canadian Precision Health Initiative (CPHI), this research will sequence 11,100 genomes from Black individuals across Ontario, Quebec, and Nova Scotia to address critical gaps in genomic research and improve treatments for chronic diseases disproportionately affecting Black populations. The initiative is expected to make a significant contribution to global precision medicine by integrating valuable insights into international genomic databases.
Tackling underrepresentation in genomic research
Despite the immense genetic diversity of African ancestry, Black individuals remain significantly underrepresented in genomic databases, limiting the potential for precision medicine in this population. This project aims to change that by sequencing both short- and long-read genomes to identify genetic markers linked to three major health conditions: hypertension, type 2 diabetes, and triple-negative breast cancer (TNBC). These diseases have higher prevalence rates and worse health outcomes among Black communities, making targeted research a crucial step in addressing health disparities.
A data-driven approach to health equity
Beyond genetic sequencing, the research team will integrate social and structural determinants of health (SSDOH) alongside genomic data to gain a more comprehensive understanding of disease susceptibility. Factors such as socioeconomic status, systemic racism, and healthcare accessibility will be analyzed to develop better diagnostic tools, early intervention strategies, and personalized treatments. By combining genetic and environmental insights, the initiative seeks to provide a more equitable approach to precision medicine.
Community engagement and ethical research
A key component of the project is its commitment to community engagement and ethical research practices. To foster trust and encourage participation, the research team has partnered with Black community organizations and healthcare providers. A Community Advisory Group will help ensure culturally safe research practices, and study materials will be available in both English and French to increase accessibility. Participants will have flexible options for informed consent, including virtual and in-person enrollment, while outreach efforts will be conducted through culturally relevant channels such as social media, radio, and community events.
National and international impact
As part of the larger $200-million Genomics Data Initiative, funded by Genome Canada, this study is expected to make a significant contribution to global precision medicine. Findings will be integrated into international genomic databases and shared with major research institutions such as the UK Biobank and the National Institutes of Health. The data will also be included in Canada’s national genomic databank, ensuring long-term benefits for future research and healthcare innovation.
“This initiative is a critical step toward equity in genomic medicine,” said Prof. Jerome-Majewska. “By ensuring broader representation in genetic research, we can develop more effective, personalized treatments that truly reflect the diversity of our population.”
Congratulations to Loydie Jerome-Majewska and her collaborators!
Related News
Canada launches $200M genomics data initiative to drive precision health and economic growth
New insights into the genetics of rare diseases