Cancer cachexia • cancer rehabilitation • nutritional evaluation • performance • quality of life • prognosis
My research aims to improve the classification, diagnosis, treatment and prevention of wasting and/or debilitating syndromes such as cachexia, sarcopenia and lymphedema, primarily in patients suffering from cancer and/or frailty. Current research interests at MNUPAL include: validation of tools for assessing nutrition and performance in advanced cancer patients, definition of relationships between molecular, nutritional and functional correlates of cancer cachexia, diagnosis and treatment of male hypogonadism in advanced cancer, prediction and prevention of surgical risks in elderly cancer patients, and evaluation of body composition in lymphedema.
Vigano AL, Di Tomasso J, Kilgour RD,Trutschnigg B, Lucar E, Morais JA Borod M.The Abridged Patient-Generated Subjective Global Assessment is a Useful Tool for Early Detection and Characterization of Cancer Cachexia. Journal of the Academy of Nutrition and Dietetics 2013 (in press)
Kilgour RD, Vigano A, Trutschnigg B, Lucar E, Borod M, Morais JA.Handgrip strength predicts survival and is associated with markers ofclinical and functional outcomes in advanced cancer patients. JSupport Care Cancer 2013; 21: 3261-3270.
Vigano A, Del Fabbro E, Bruera E, Borod M. The cachexia clinic: from staging to managing nutritional and functional problems in advancer cancer patients. Critical Reviews in Oncogenesis 2012 17(3), 293–304
A. Vigano, M. Piccioni, B. Trutschnigg, L. Hornby, P. Chaudhury, R.D. Kilgour. Functional, Nutritional and Quality of Life Correlates of Hypogonadism in Advanced Cancer: A Qualitative Systematic Review of the Literature. Lancet Oncol. 2010 Jul;11(7):679-84
Vigano A, Trutschnigg B, Kilgour RD, Hamel N, Hornby L, Lucar E, Foulkes W, Tremblay M, Morais JA. Relationship between angiotensin-converting enzyme gene polymorphism and body composition, functional performance, and blood biomarkers in advanced cancer patients. Clin Cancer Res. 2009 Mar 3.