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null Carolyn Baglole, PhD

Scientist, RI-MUHC, Glen site

Translational Research in Respiratory Diseases Program

Centre for Translational Biology

Associate Professor, Department of Medicine, Faculty of Medicine and Health Sciences, McGill University

Department of Medicine, Division of Respiratory Medicine, MUHC

 

Keywords

chronic obstructive pulmonary disease • toxicology • cigarette smoke • inflammation • lungs

Research Focus

My research program consists of three overlapping themes centred on inhalation toxicology and respiratory disease respiratory disease pathogenesis. These themes are tobacco, cannabis and pulmonary fibrosis.

Tobacco smoke causes many lung diseases, and there is now a surge in the use of e-cigarettes, where the long-term health effects are unknown. Therefore, we use preclinical models of tobacco and e-cigarette exposure to understand the pathogenesis of respiratory disease.

Cannabis is mostly consumed via inhalation, but the safety and efficacy of cannabis products are largely unknown. We have established a preclinical pipeline to test inhaled cannabis, cannabinoids and novel drugs in various preclinical disease models.

Pulmonary fibrosis causes the lungs to become scarred, leading to death from respiratory failure. Risk factors for pulmonary fibrosis include cigarette smoke. There is no cure for pulmonary fibrosis and treatment options are few. Therefore, we seek to identify novel cellular pathways that can be used as therapeutic targets against fibrotic disease.

Selected Publications

Click on Pubmed to see my current publications list

  • Paoli S, Eidelman DH, Mann KK and Baglole CJ. Sex-specific alterations in pulmonary metabolic, xenobiotic and lipid signaling pathways after e-cigarette aerosol exposure during adolescence in mice. BMJ Open Resp Res. 11(1): e002423; 1-15, 2024. DOI: 10.1136/bmjresp-2024-002423.

  • Caruana V, Giles B, Kukol N, Juran R, Baglole CJ* and Mann KK*. Chronic Exposure to E-cigarette Aerosols Potentiates Atherosclerosis in a Sex-Dependent Manner. Toxicol. Applied Pharmacol. 491:1-11, 2024. *Co-senior authors. DOI: 10.1016/j.taap.2024.117095.

  • Been T, Alakhtar B, Traboulsi H, Tsering T, Bartolomucci A, Heimbach N, Paoli S, Burnier J, Mann KK, Eidelman DH and Baglole CJ. Chronic low level JUUL aerosol exposure causes pulmonary immunologic, transcriptomic, and proteomic changes. FASEB J. 37; e22732, 2023. DOI: 10.1096/fj.202201392R.

  • Al-Habeeb F, Aloufi N, Traboulsi H, Liu X, Nair P, Haston C, Azuelos I, Huang SK, White ES, Gallouzi IE, Di Marco S, Eidelman DH and Baglole CJ. Human antigen R promotes lung fibroblast differentiation to myofibroblasts and increases extracellular matrix production. J Cell. Physiol. 10, 2021. DOI: 10.1002/jcp.30380.

  • Guerrina N, Traboulsi H, Rico de Souza A, Bossé Y, Thatcher TH, Robichaud A, Ding J, Li PZ, Simon L, Pareek S, Bourbeau J, Tan WC, Benedetti A, Obeidat M, Sin DD, Brandsma C, Nickle DC, Sime PJ, Phipps RP, Nair P, Zago M, Hamid Q, Smith B, Eidelman DH and Baglole CJ. Aryl hydrocarbon receptor deficiency causes the development of chronic obstructive pulmonary disease through the integration of multiple pathogenic mechanisms. FASEB J. 35:3, 2021. DOI: 10.1096/fj.202002350R.