epidermal growth factor receptor (EGFR) • Ras protein • Caenorhabditis elegans • Rab proteins • vesicular trafficking
My research focuses on understanding the mechanisms that regulate two fundamental cellular processes, cell signaling and protein trafficking, and interactions between these processes using genetic, cell biological and biochemical approaches. I use the nematode Caenorhabditis elegans as a model system. This simple worm allows us to study gene function, not only at the cellular level, but also in the context of animal development and physiology. The high conservation of genes between C. elegans and H. sapiens means that findings made in the worm will be relevant to human health.
Law F*, Seo J-H*, Wang Z, DeLeon JL, Bolis Y, Brown A, Zong W-X, Du G and Rocheleau CE (2017) The VPS-34 PI3 kinase negatively regulates RAB-5 during endosome maturation. Journal of Cell Science 130, 2007-2017. PMID: 28455411.
Skorobogata O*, Meng J*, Gauthier K and Rocheleau CE (2016). Dynein-mediated trafficking negatively regulates LET-23 EGFR signaling. Molecular Biology of the Cell, 27, 3771-3779. PMID: 27654944.
Skorobogata O, Escobar-Restrepo JM and Rocheleau CE (2014) An AGEF-1/Arf GTPase/AP-1 ensemble antagonizes LET-23 EGFR basolateral localization and signaling during C. elegans vulva induction. PLoS Genetics,10, e1004728. PMID: 25329472.
Skorobogata O and Rocheleau CE (2012). RAB-7 antagonizes LET-23 EGFR signaling during vulva development in Caenorhabditis elegans. PLoS ONE, 7, e36489. PMID: 22558469.
Chotard L, Mishra AK, Sylvain MA, Tuck S, Lambright DG and Rocheleau CE (2010) TBC-2 regulates RAB-5/RAB-7-mediated endosomal trafficking in C. elegans. Molecular Biology of the Cell, 21, 2285-2296. PMID: 20462958.