null Christian Rocheleau, PhD
epidermal growth factor receptor (EGFR) • Ras protein • Caenorhabditis elegans • Rab proteins • vesicular trafficking
My research focuses on understanding the mechanisms that regulate two fundamental cellular processes, cell signaling and protein trafficking, and interactions between these processes using genetic, cell biological and biochemical approaches. I use the nematode Caenorhabditis elegans as a model system. This simple worm allows us to study gene function, not only at the cellular level, but also in the context of animal development and physiology. The high conservation of genes between C. elegans and H. sapiens means that findings made in the worm will be relevant to human health.
Meraş İ, Chotard L, Liontis T, Ratemi Z, Wiles B, Seo J-H, Van Raamsdonk JM and Rocheleau CE (2021). The Rab GTPase activating protein TBC-2 extends longevity by facilitating release of FOXO/DAF-16 from endosomes. bioRxiv https://doi.org/10.1101/2021.06.04.447106.
Gauthier KD and Rocheleau CE (2021). LIN-10 can promote LET-23 EGFR signaling and trafficking independently of LIN-2 and LIN-7. Molecular Biology of the Cell 32, 788-799. PMID: 33566630.
Gauthier KD and Rocheleau CE (2021). Golgi localization of the LIN-2/7/10 complex points to a role in basolateral secretion of LET-23 EGFR in the C. elegans vulval precursor cells. Development 148, dev 194167. PMID: 33526581.
Ratemi Z, Kiss RS and Rocheleau CE (2019). C. elegans rab-18 mutants display reduced lipid content under fed and fasted conditions. microPublication Biology 10.17912/micropub.biology.000188. PMID: 32550463.
Law F*, Seo J-H*, Wang Z, DeLeon JL, Bolis Y, Brown A, Zong W-X, Du G and Rocheleau CE (2017). The VPS-34 PI3 kinase negatively regulates RAB-5 during endosome maturation. Journal of Cell Science 130, 2007-2017. PMID: 28455411.