null CORE Seminar series 2: Biostatistical principles & practices

Dr Linda Valeri, PhD
Dr Linda Valeri, PhD

When: Wednesday, March 24, 2021 at 4 pm

Where: Online virtual seminars during the COVID-19 pandemic

Presenter: Dr Linda Valeri, PhD
Assistant Professor of Biostatistics
Mailman School of Public Health
Columbia University

Topic: Mediation analysis when outcome and mediator are semi-competing events with application in health disparities research

We provide novel definitions and identifiability conditions for causal estimands that involve stochastic interventions on non-terminal time-to-events that lie on the pathway between an exposure and a terminal time-to-event outcome. Causal contrasts are estimated in continuous time within a multistate modeling framework accounting for semi-competing risks and analytic formulae for the estimators of the causal contrasts are developed. We employ this novel methodology to investigate the role of delaying treatment uptake in explaining racial disparities in cancer survival in a cohort study of colon cancer patients.

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The presentation will be delivered in English.