Breadcrumb

null Giada Sebastiani, MD

Senior Scientist, RI-MUHC, 5252 de Maisonneuve site

Infectious Diseases and Immunity in Global Health Program

Centre for Outcomes Research and Evaluation

Professor, Department of Medicine, Faculty of Medicine and Health Sciences, McGill University

Department of Medicine, Division of Gastroenterology, MUHC

 

Keywords

fatty liver • serum liver biomarkers • elastography • HIV • hepatitis C • hepatitis B

Research Focus

My research focuses on screening for liver fibrosis and fatty liver of at-risk populations, including HIV+ patients, patients with diabetes and obesity, women with polycystic ovary syndrome, and patients with inflammatory bowel syndrome. To conduct these studies, I employ serum fibrosis biomarkers and a non-invasive machine, which is ultrasound-based, named Fibroscan. I am also site investigator of multiple global clinical trials for antifibrotic compounds in NASH.

Selected Publications

Click on Pubmed to see my current publications list

  • Association Between Fibrosis Stage and Outcomes of Patients With Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis. Taylor RS, Taylor RJ, Bayliss S, Hagström H, Nasr P, Schattenberg JM, Ishigami M, Toyoda H, Wai-Sun Wong V, Peleg N, Shlomai A, Sebastiani G, Seko Y, Bhala N, Younossi ZM, Anstee QM, McPherson S, Newsome PN. Gastroenterology. 2020 May;158(6):1611-1625.e12. doi: 10.1053/j.gastro.2020.01.043. Epub 2020 Feb 4. PMID: 32027911.

  • New Drugs for NASH and HIV Infection: Great Expectations for a Great Need. Guaraldi G, Maurice JB, Marzolini C, Monteith K, Milic J, Tsochatzis E, Bhagani S, Morse CG, Price JC, Ingiliz P, Lemoine M, Sebastiani G; SHIVER Network. Hepatology. 2020 May;71(5):1831-1844. doi: 10.1002/hep.31177. PMID: 32052857.

  • Burden of nonalcoholic fatty liver disease in Canada, 2019-2030: a modelling study. Swain MG, Ramji A, Patel K, Sebastiani G, Shaheen AA, Tam E, Marotta P, Elkhashab M, Bajaj HS, Estes C, Razavi H. CMAJ Open. 2020 Jun 9;8(2):E429-E436. doi: 10.9778/cmajo.20190212. Print 2020 Apr-Jun. PMID: 32518095.

  • Vitamin E is an effective treatment for nonalcoholic steatohepatitis in HIV mono-infected patients. Sebastiani G, Saeed S, Lebouche B, de Pokomandy A, Szabo J, Haraoui LP, Routy JP, Wong P, Deschenes M, Ghali P, Klein M; LIVEHIV Study Group. AIDS. 2020 Feb 1;34(2):237-244. doi: 10.1097/QAD.0000000000002412. PMID: 31651429.

  • Prevalence, Predictors, and Severity of Lean Nonalcoholic Fatty Liver Disease in Patients Living With Human Immunodeficiency Virus. Cervo A, Milic J, Mazzola G, Schepis F, Petta S, Krahn T, Lebouche B, Deschenes M, Cascio A, Guaraldi G, Sebastiani G. Clin Infect Dis. 2020 Dec 17;71(10):e694-e701. doi: 10.1093/cid/ciaa430. PMID: 32280969.