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null Gregory Fonseca, PhD

Scientist, RI-MUHC, Glen site

Translational Research in Respiratory Diseases Program

Centre for Translational Biology

Assistant Professor, Department of Medicine, Faculty of Medicine and Health Sciences, McGill University

 

Keywords

machine learning • transcriptomics • epigenomics • alveolar macrophages

Research Focus

Inflammation is central to many diseases. It is a signalling process transmitted by dozens of signalling molecules in many combinations. Our lab focuses on understanding the types of inflammation in the lung that lead to disease. We use machine learning models on next-generation sequencing datasets to predict patterns associated with cytokine activation and use these to deconvolute the inflammatory response as seen by the resident macrophage population.

Selected Publications

Click on Pubmed to see my current publications list

  • Fonseca GJ, Tao J, et. al. Diverse motif ensembles specify non-redundant DNA binding activities of AP-1 family members in macrophages. Nat Commun. 2019 Jan 24;10(1):414. PMID: 30679424.

  • Lopez-Ramirez MA, Fonseca G, et. a. Thrombospondin1 (TSP1) replacement prevents cerebral cavernous malformations. J Exp Med. 2017 Nov 6;214(11):3331-3346. PMID: 28970240.

  • Sajti E, Link VM, Ouyang Z, Spann NJ, Westin E, Romanoski CE, Fonseca GJ, Prince LS, Glass CK. Transcriptomic and epigenetic mechanisms underlying myeloid diversity in the lung. Nat Immunol. 2020 Feb;21(2):221-231. PMID: 31959980.