congenital kidney and urinary tract defects • children
My research focuses on understanding the basis for congenital defects in the kidneys and urinary tracts. These disorders account for 40% of all cases of kidney failure in children and result in dialysis and transplantation for those affected children. My laboratory is using cell lines, animal models and samples from affected children to understand these defects and eventually identify new therapeutic possibilities.
Murawski IJ*, Maina R*, Malo D, Guay-Woodford L, Gros P, Fujiwara M, Morgan K, Gupta IR. The C3H/HeJ Mouse is a Model of Vesico-ureteric Reflux and Has a Susceptibility Locus on Chromosome 12, Kidney Int; 78(3): 269-278, 2010. PMID: 20407478.
Haddad N*, El Andalousi J, Khairallah H*, Yu M*, Ryan AK, Gupta IR. The tight junction protein claudin-3 shows conserved expression in the nephric duct and ureteric bud and promotes tubulogenesis in vitro. American Journal of Physiology Renal Physiology; 301(5):F1057-65, 2011. PMID: 21775479.
El Andalousi, J**, Murawski*, IJ, Capolicchio, JP, El-Sherbiny, M, Jednak, R, Gupta, IR. A Single Center Cohort of Canadian Children with VUR Reveals Specific henotypes Important for Genetic Studies, Pediatric Nephrology 28(9):1813-9, 2013.
Gupta, IR, Baldwin, C, Auguste, D, Ha, KCH, El Andalousi, J**, Fahiminiya, S, Bitzan,M, Bernard, C, Akbar, MR, Narod, SA., Rosenblatt, DS, Majewski, J, Takano, T. ARHGDIA: a novel gene implicated in nephrotic syndrome, Journal of Medical Genetics; 50(5):330-8, 2013. PMID: 23434736.
Bowen, S, Watt, C.L*., Murawski, I.J.*, Gupta, I.R., Abraham, S.N. Interplay between vesico-ureteric reflux and kidney infection in the development of reflux nephropathy. Dis Model Mech; 6(4):934-41, 2013. PMID: 23519031.