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angle-left Jason Karamchandani, MD

Investigator, RI-MUHC , Montreal Neurological Institute and Hospital

Brain Repair and Integrative Neuroscience (BRaIN) Program

Montreal Neurological Institute

Associate Professor, Department of Pathology, Faculty of Medicine, McGill University

Department of Clinical Laboratory Medicine, Division of Pathology, MUHC

 

Keywords


neuropathology • bioinformatics • neuro-oncology • surgical pathology • neuromuscular pathology

Research Focus


My research focuses on leveraging bioinformatic data to identify potential diagnostic, prognostic, and predictive markers in neuro-oncology and neuromuscular disease.

Selected Publications


Click on Pubmed to see my current publications list

  • Recessive mutations in VPS13D cause childhood onset movement disorders. Gauthier J, Meijer IA, Lessel D, Mencacci NE, Krainc D, Hempel M, Tsiakas K, Prokisch H, Rossignol E, Helm MH, Rodan LH, Karamchandani J, Carecchio M, Lubbe SJ, Telegrafi A, Henderson LB, Lorenzo K, Wallace SE, Glass IA, Hamdan FF, Michaud JL, Rouleau GA, Campeau PM. Ann Neurol. 2018 Jun;83(6):1089-1095. doi: 10.1002/ana.25204. Epub 2018 Apr 10. PMID: 29518281.

  • Spatial and temporal homogeneity of driver mutations in diffuse intrinsic pontine glioma. Nikbakht H, Panditharatna E, Mikael LG, Li R, Gayden T, Osmond M, Ho CY, Kambhampati M, Hwang EI, Faury D, Siu A, Papillon-Cavanagh S, Bechet D, Ligon KL, Ellezam B, Ingram WJ, Stinson C, Moore AS, Warren KE, Karamchandani J, Packer RJ, Jabado N, Majewski J, Nazarian J.Nat Commun. 2016 Apr 6;7:11185. doi: 10.1038/ncomms11185. PMID: 27048880.

  • DNA hypermethylation within TERT promoter upregulates TERT expression in cancer. Lee DD, Leão R, Komosa M, Gallo M, Zhang CH, Lipman T, Remke M, Heidari A, Nunes NM, Apolónio JD, Price AJ, De Mello RA, Dias JS, Huntsman D, Hermanns T, Wild PJ, Vanner R, Zadeh G, Karamchandani J, Das S, Taylor MD, Hawkins CE, Wasserman JD, Figueiredo A, Hamilton RJ, Minden MD, Wani K, Diplas B, Yan H, Aldape K, Akbari MR, Danesh A, Pugh TJ, Dirks PB, Castelo-Branco P, Tabori U. J Clin Invest. 2019 Jan 2;129(1):223-229. doi: 10.1172/JCI121303. Epub 2018 Dec 3. PMID: 30358567.

  • Characterizing temporal genomic heterogeneity in pediatric high-grade gliomas. Salloum R, McConechy MK, Mikael LG, Fuller C, Drissi R, DeWire M, Nikbakht H, De Jay N, Yang X, Boue D, Chow LML, Finlay JL, Gayden T, Karamchandani J, Hummel TR, Olshefski R, Osorio DS, Stevenson C, Kleinman CL, Majewski J, Fouladi M, Jabado N. Acta Neuropathol Commun. 2017 Oct 30;5(1):78. doi: 10.1186/s40478-017-0479-8. PMID: 29084603.

  • Molecular Genetics of Secondary Glioblastoma. Mansouri A, Karamchandani J, Das S. In: De Vleeschouwer S, editor. Glioblastoma [Internet]. Brisbane (AU): Codon Publications; 2017 Sep 27. Chapter 2. PMID: 29251857.