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null Joanna Przybyl, PhD

Junior Scientist, RI-MUHC , Glen site

Cancer Research Program

Centre for Translational Biology

 

Keywords


sarcoma • liquid biopsy • metabolic reprogramming • translational research • multiomics

Research Focus


In my research I employ multi-omic high-throughput experimental methods and bioinformatic tools to discover new therapeutic targets and markers for diagnosis and classification of soft tissue sarcomas. The goal of my research is to develop clinically applicable assays and investigate new therapeutic approaches that will improve care for patients with soft tissue tumours.

Selected Publications


Click on Pubmed to see my current publications list

  • Tolwani A, Matusiak M, Bui, N, Forgo E, Varma S, Baratto L, Iagaru A, Lazar AJ, van de Rijn M, Przybyl J. Prognostic relevance of the hexosamine biosynthesis pathway activation in leiomyosarcoma. npj Genomic Medicine. 2021 May 3;6(1):30. doi: 10.1038/s41525-021-00193-w. PMID: 33941787.

  • Przybyl J, Spans L, Lum D, Zhu S, Vennam S, Forgó E, Varma S, Ganjoo K, Hastie T, Bowen R, Debiec-Rychter M, van de Rijn M. Detection of circulating tumor DNA in patients with uterine leiomyomas. JCO Precision Oncology. 2019 Oct 16;3:1-9. PMID: 32232185.

  • Przybyl J*, Chabon JJ*, Spans L, Ganjoo K, Vennam S, Newman AM, Forgó E, Varma S, Zhu S, Debiec-Rychter M, Alizadeh AA, Diehn M, van de Rijn M. Combination approach for detecting different types of alterations in circulating tumor DNA in leiomyosarcoma. Clin Cancer Res. 2018 Jun 1;24(11):2688-2699. PMID: 29463554.

  • Przybyl J, Kowalewska M, Quattrone A, Dewaele B, Vanspauwen V, Varma S, Vennam S, Newman AM, Swierniak M, Bakuła-Zalewska E, Siedlecki JA, Bidzinski M, Cools J, van de Rijn M, Debiec-Rychter M. Macrophage infiltration and genetic landscape of undifferentiated uterine sarcomas. JCI Insight. 2017 Jun 2;2(11). PMID: 28570276.

  • Lagarde P*, Przybyl J*, Brulard C, Pérot G, Pierron G, Delattre O, Sciot R, Wozniak A, Schöffski P, Terrier P, Neuville A, Coindre JM, Italiano A, Orbach D, Debiec-Rychter M, Chibon F. Chromosome instability accounts for reverse metastatic outcomes of pediatric and adult synovial sarcomas. J Clin Oncol. 2013 Feb 10;31(5):608-15. PMID: 23319690.