Breadcrumb

null Luke Harrison, MD, PhD

Junior Scientist, RI-MUHC, Glen site

Infectious Diseases and Immunity in Global Health Program

Centre for Translational Biology

Associate Professor, Department of Medicine, Faculty of Medicine and Health Sciences, McGill University

Department of Medicine, Division of Infectious Diseases, MUHC

 

Keywords

mycobacteria • metagenomics • infectious diseases • medical microbiology • tuberculosis

Research Focus

My research program focuses on the evolution and pathobiology of mycobacteria, integrating comparative genomics and metagenomics to study Mycobacterium tuberculosis and non-tuberculous mycobacterial infections. My current projects aim to elucidate the genomic dynamics of non-tuberculous mycobacterial infections through direct metagenomic sequencing and to develop computational tools for comparative genomic analysis within the M. tuberculosis complex. My overarching goal is to link microbial evolution with clinical outcomes to improve the diagnosis and understanding of mycobacterial disease.

Selected Publications

Click on Pubmed to see my current publications list

  • Harrison LB, JO Ahmed, G Coulibaly, and FJ Veyrier. Comparative performance of reference-based metagenomic tools to identify species-level taxa among families of bacteria: benchmarking Mycobacteriaceae and Neisseriaceae. Available at BioRxiv: https://www.biorxiv.org/content/10.1101/2025.06.23.661092v1.

  • Harrison LB, V Kapur, and MA Behr (2024) An imputed ancestral reference genome for the Mycobacterium tuberculosis complex better captures structural genomic diversity for reference-based alignment workflows. Microbial Genomics, 10(1):001165 https://doi.org/10.1099/mgen.0.001165.

  • Harrison LB, G Bergeron, G Cadieux, H Charest, J Fafard, I Levade, AC Blais, E Huchet, B Trottier, D Vlad, J Szabo, R Thomas, S Poulin, C Greenaway, GJ Zaharatos, M Oughton, A Chakravarti, R Pilarski, A Bui-Nguyen, K Benomar, MD Libman, DC Vinh, AT Duggan, M Graham, MB Klein, and S Barkati (2022) Monkeypox in Montréal: Epidemiology, Phylogenomics, and Public Health Response to a Large North American Outbreak. Annals of Internal Medicine, 176(1):1-11. https://doi.org/10.7326/M22-2699.