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null Matthieu Allez, MD, PhD

Investigator, RI-MUHC, Glen site

Infectious Diseases and Immunity in Global Health Program

Professor, Department of Medicine, Faculty of Medicine and Health Sciences, McGill University

 

Keywords

translational IBD research • gene expression • T cell repertoire • multiomic analysis • biomarkers • advanced targeted therapies

Research Focus

My research focuses on inflammatory bowel diseases, a group of immune-mediated inflammatory disorders marked by chronic inflammation of the intestinal mucosa. I investigate the role of innate and adaptive immunity and am interested in a variety of models to study the causes and mechanisms of these diseases, including studying the postoperative relapse – why some patients experience recurrence while others do not -, as well as response to advanced therapies. The overarching goals of my work are to better characterize disease subtypes, identify biomarkers that predict therapeutic outcomes, and uncover optimal combinations and novel therapeutic targets.

Selected Publications

Click on Pubmed to see my current publications list

  • Pesesky M, Bharanikumar R, Le Bourhis L, ElAbd H, Rosati E, Carty CL, Singh N, Bokemeyer B, Schreiber S, Görg S, Noceda MG, Chapfuwa P, Gittelman RM, May D, Dines JN, Zhou W, Kaplan IM, Snyder TM, Jabran Zahid H, Greissl J, Chen-Harris H, Howie B, Franke A, Robins HS, Allez M. Antigen-driven expansion of public clonal T cell populations in inflammatory bowel diseases. J Crohns Colitis. 2025 Mar 22:jjaf048. doi: 10.1093/ecco-jcc/jjaf048. PMID: 40121186.

  • Allez M, Skolnick BE, Wisniewska-Jarosinska M, Petryka R, Overgaard RV. Anti-NKG2D monoclonal antibody (NNC0142-0002) in active Crohn's disease: a randomised controlled trial. Gut. 2017 Nov;66(11):1918-1925. doi: 10.1136/gutjnl-2016-311824. PMID: 27489241.

  • Hammoudi N, Hamoudi S, Bonnereau J, Bottois H, Pérez K, Bezault M, Hassid D, Chardiny V, Grand C, Gergaud B, Bonnet J, Chedouba L, Tran Minh ML, Gornet JM, Baudry C, Corte H, Maggiori L, Toubert A, McBride J, Brochier C, Neighbors M, Le Bourhis L, Allez M. Autologous organoid co-culture model reveals T cell-driven epithelial cell death in Crohn's Disease. Front Immunol. 2022 Nov 10;13:1008456. doi: 10.3389/fimmu.2022.1008456. eCollection 2022. PMID: 36439157.

  • Ngollo M, Perez K, Hammoudi N, Gorelik Y, Delord M, Auzolle C, Bottois H, Cazals-Hatem D, Bezault M, Nancey S, Nachury M, Treton X, Fumery M, Buisson A, Barnich N, Seksik P; REMIND Study Group Investigators; Shen-Orr SS, Le Bourhis L, Allez M. Identification of Gene Expression Profiles Associated with an Increased Risk of Post-Operative Recurrence in Crohn's Disease. J Crohns Colitis. 2022 Aug 30;16(8):1269-1280. doi: 10.1093/ecco-jcc/jjac021. PMID: 35143619.

  • Allez M, Mayer L. Regulatory T cells: peace keepers in the gut. Inflamm Bowel Dis. 2004 Sep;10(5):666-76. doi: 10.1097/00054725-200409000-00027. PMID: 15472533.