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null Nicole Li-Jessen, PhD

Associate Investigator, RI-MUHC

Translational Research in Respiratory Diseases Program

Professor, Department of Surgery, Faculty of Medicine and Health Sciences, McGill University

 

Keywords

upper airway health and diseases • computational medicine • tissue engingeering • point-of-care diagnostics • wearable devices

Research Focus

My research focuses on advancing personalized medicine in voice and upper airway dysfunctions through the development of New Approach Methodologies (NAMs), regenerative materials and digital wearables. My team is developing Digital twins of upper airway, biomimetic organ-on-chips, injectable biomaterial for laryngeal tissue and muscle reconstruction and creating wearable e-health devices for voice and upper airway monitoring. My work is funded by a Canada Research Chair, the CIHR, NSERC, SSHRC and FRQS, and by NIH in the United States.

Selected Publications

Click on Pubmed to see my current publications list

  • Munipalle, M., Dang, A., Celiz, A., Li, J. Y. & Li‐Jessen, N. Y. K. Computational Advances in Biomaterial Engineering: Mapping Research Trajectories Through Bibliometric Analysis. Tissue Eng Part B Rev. 2026 May 23:19373368261449957. PMID: 42175949.

  • Okuyama H., Brown, M., Munipalle, M., Nejati, S., Huo, R., Sakata, H., Mizuta, R., Sasaki, Y., Akiyoshi, K., Ohnishi, H., Kishimoto, Y., Omori, K., Li, J. Y., Mongeau, L. & Li‐Jessen, N. Y. K. Click-crosslinked nanogels integrated into 3D stem cell spheroids enhance regenerative function for swallowing muscle repair. Biomaterials. 2026 Jul;330:124044. PMID: 41650592.

  • Brown, M., Okuyama H., Li, Ling, Yang, Z., Li, J. Y., Tabrizian, M.† & Li‐Jessen, N. Y. K.†. Click-tetrazine dECM–alginate hydrogels for injectable, mechanically mimetic, and biologically active vocal fold biomaterials. Biomaterials. 2026 Feb. 325:123590. † Co-senior authors. PMID: 40784130.

  • Chao, A., Martignetti, L., Groh, R., Kist, A., & Li‐Jessen, N. Y. K. (2025). An mHealth App and System Architecture for Respiratory Disease Management: Design Principles, Tool Development, and Pilot Usability Study. JMIR Form Res. 2025 Oct 29;9:e73584. PMID: 41161341.

  • Landry, V., Matschek, J., Pang, R., Munipalle, M., Tan, K., Boruff, J. & Li‐Jessen, N. Y. K. (2025). Audio-based digital biomarkers in diagnosing and managing respiratory diseases: a systematic review and bibliometric analysis. Eur Respir Rev. 2025 May 14;34(176):240246. PMID: 40368428.