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null Paraish Misra, MD, PhD, FRCPC

Junior Scientist, RI-MUHC, Glen site

Metabolic Disorders and Complications Program

Centre for Translational Biology

Assistant Professor, Department of Medicine, Faculty of Medicine and Health Sciences, McGill University

Department of Medicine, Division of Nephrology, MUHC

 

Keywords

human pluripotent stem cells • transplantation • personalized medicine • immunosuppression • development

Research Focus

My research focuses on using human pluripotent stem cells to build personalised, next-generation cell therapies for people who need organ transplants. In my lab, we generate patient-derived induced pluripotent stem cells (iPSCs) to create organ-like tissues that recreate each patient’s own biology in vitro. We then differentiate these iPSCs into multiple specialised lineages, including islet, thymus, endothelial, macrophage and kidney cells. By studying these personalised iPSC-based models, we aim to understand and control how the immune system responds to transplanted cells and to make cell-based therapies safer, more durable and more precisely matched to each individual.

Selected Publications

Click on Pubmed to see my current publications list

  • Misra PS, McGaugh EC, Huang H, Cho A, Lin J, Sarangi F, Oakie A, Sambathkumar R, Song Y, Fabríciová V, Bohuslavová R, Pavlínková G, Nostro MC. Efficient control of enterochromaffin versus islet differentiation from human pluripotent stem cell-derived pancreatic progenitors. Nat Commun. 2026;[volume(issue) and article number pending at time of writing]. doi: 10.1038/s41467-026-70666-y. PMID: 41851084.

  • Colpitts SJ, Jegatheeswaran S, Oakie A, Mashhouri S, Sachewsky N, Murshed H, Mathews JA, Reid KT, Misra PS, Fung VCW, Reichman TW, Nostro MC, Verchere CB, Levings MK, Crome SQ. Cell therapy with human interleukin 10-producing ILC2s enhances islet function and inhibits allograft rejection. Am J Transplant. 2025 Sep;25(9):1858–1869. doi: 10.1016/j.ajt.2025.05.023. PMID: 40412656.

  • Poon F, Sambathkumar R, Korytnikov R, Aghazadeh Y, Oakie A, Misra PS, Sarangi F, Nostro MC. Tankyrase inhibition promotes endocrine commitment of hPSC-derived pancreatic progenitors. Nat Commun. 2024 Oct 9;15(1):8754. doi: 10.1038/s41467-024-53068-w. PMID: 39384787.

  • Misra PS, Nostro MC. Designing next-generation islet-like cells from human pluripotent stem cells: advances in overcoming allorejection and recurrent type 1 diabetes. Curr Opin Endocrinol Metab Res. 2022;100321. doi: 10.1016/j.coemr.2022.100321.

  • Misra PS, Nostro MC. Islet-resident endocrine progenitors: a new hope for beta cell PROCReation? Cell Stem Cell. 2020 May 7;26(5):577–578. doi: 10.1016/j.stem.2020.03.008. PMID: 32243804.