null Rahul Gawri, MD, PhD
osteoimmunology • fracture healing • mast cells • disc degeneration • low back pain
My research focuses on fracture healing using the body’s immune cells, such as mast cells, and devising strategies for faster and more effective repair. I also conduct research on bioenergetics and energy utilization by cells that generally have a limited nutrient supply, such as intervertebral disc cells and cells at the site of fracture healing. The overall goal of this research is to utilize innate mechanisms and energy modulation to devise effective tissue engineering therapies.
Gawri R, Shiba T, Pilliar R, Kandel R. Inorganic polyphosphates enhances nucleus pulposus tissue formation in vitro. J Orthop Res. 2017 Jan;35(1):41-50. doi: 10.1002/jor.23288. Epub 2016 May 30. PMID: 27164002.
Lee WD, Gawri R, Shiba T, Ji AR, Stanford WL, Kandel RA. Simple Silica Column-Based Method to Quantify Inorganic Polyphosphates in Cartilage and Other Tissues. Cartilage. 2018 Oct;9(4):417-427. doi: 10.1177/1947603517690856. Epub 2017 Mar 16. PMID: 28357919.
Lee WD, Gawri R, Pilliar RM, Stanford WL, Kandel RA. Sol gel-derived hydroxyapatite films over porous calcium polyphosphate substrates for improved tissue engineering of osteochondral-like constructs. Acta Biomater. 2017 Oct 15;62:352-361. doi: 10.1016/j.actbio.2017.08.016. Epub 2017 Aug 14. PMID: 28818689.
Gawri R, Ouellet J, Önnerfjord P, Alkhatib B, Steffen T, Heinegård D, Roughley P, Antoniou J, Mwale F, Haglund L. Link N is cleaved by human annulus fibrosus cells generating a fragment with retained biological activity. J Orthop Res. 2014 Sep;32(9):1189-97. doi: 10.1002/jor.22653. Epub 2014 May 23. PMID: 24861010.
Gawri R, Moir J, Ouellet J, Beckman L, Steffen T, Roughley P, Haglund L. Physiological loading can restore the proteoglycan content in a model of early IVD degeneration. PLoS One. 2014;9(7):e101233. doi: 10.1371/journal.pone.0101233. eCollection 2014. PMID: 24992586.