neuroendocrinology • behavior • development • mental illness • steroid hormones
My research focuses on distinct areas of behavioral and developmental neuroendocrinology. I have been examining the impact of steroid hormones on the central nervous system for several years, more specifically the effects of androgens on brain structure and behavior during the pubertal period. During my training, I expanded this research focus to include the examination of sex steroid receptor expression in postmortem human brain, and the effects of sex steroid receptor genotype on brain structure. My long-term goal is to move beyond the examination of steroid hormones in isolation and to focus my efforts on integrating the examination of steroid hormones with that of steroid receptor expression, neurotransmitter function, and clinically significant phenotypes such as premenstrual dysphoric disorder, postpartum depression and perimenopausal-related mood as well as anxiety disorders.
Nguyen TV. Developmental Effects of Androgens in the Human Brain, Journal of neuroendocrinology, 2018 Feb; 30(2). PMID: 28489322.
Nguyen TV, Wu M, Lew J, Albaugh MD, Botteron KN, Hudziak JJ, Fonov VS, Collins DL, Campbell BC, Booij L, Herba C, Monnier P, Ducharme S, McCracken JT. Dehydroepiandrosterone impacts working memory by shaping cortico-hippocampal structural covariance during development, Psychoneuroendocrinology, 2017 Dec; 86: 110-121. PMID: 28946055.
Nguyen TV, Ducharme S, Karama S. Effects of sex steroids in the human brain, Molecular Neurobiology, 2017 Nov; 54(9): 7507-7519. PMID: 27822715.
Nguyen TV, Reuter JM, Gaikwad NW, Rotroff DM, Kucera HR, Motsinger-Reif A, Smith CP, Nieman LK, Rubinow DR, Kaddurah-Daouk R, Schmidt PJ. The steroid metabolome in women with premenstrual dysphoric disorder during GnRH agonist-induced ovarian suppression: effects of estradiol and progesterone addback, Translational psychiatry, 2017 Aug 8; 7(8): e1193. PMID: 28786978.
Nguyen TV, Lew J, Albaugh MD, Botteron KN, Hudziak JJ, Fonov VS, Collins DL, Ducharme S, McCracken JT. Sex-specific associations of testosterone with prefrontal-hippocampal development and executive function, Psychoneuroendocrinology, 2017 Feb; 76: 206-217. PMID: 27984812.