RI-MUHC Annual Report





A clinical trial that could change how we treat dementia

Clinical psychologist and scientist Lisa Koski, PhD, and her team are wrapping up an international collaboration that seeks to identify a new treatment for dementia. The clinical trial investigates how a non-invasive therapy, repetitive transcranial magnetic stimulation (rTMS), can treat symptoms of Alzheimer's disease by inducing brain plasticity.

Toward a better understanding of neurodevelopmental disorders

Early career researcher Wei-Hsiang Huang, PhD, and his team strive to understand how the brain develops and what occurs in neurodevelopmental disorders such as autism and Smith–Magenis syndrome (SMS). They were recently able to reverse some of the behavioural phenotypes of Smith-Magenis syndrome in mice by overexpressing the gene of a protein known as BDNF, paving the way to the development of new therapies. (Human Molecular Genetics)

RI-MUHC researchers Lisa Koski, PhD, and Wei-Hsiang Huang, PhD
RI-MUHC researchers Lisa Koski, PhD, and Wei-Hsiang Huang, PhD

A multidisciplinary team to develop new treatments for vision loss

A multidisciplinary team of researchers at the RI-MUHC, including BRaIN Program scientists Janine Mendola, PhD, Amir Shmuel, PhD, and Leonard Levin, PhD, have started to test patients with traumatic optic neuropathy. The goal of this large research project is to go from drug development to clinical testing by creating a state-of-the-art brain analysis pipeline, using machine learning tools, with the goal of predicting clinical outcome.

Janine Mendola, PhD, Leonard Levin, PhD, and Amir Shmuel, PhD (left to right)
Janine Mendola, PhD, Leonard Levin, PhD, and Amir Shmuel, PhD (left to right)

Selected BRaIN Program news links



Zahra S. Thirouin, Charles W. Bourque. Mechanism and function of phasic firing in vasopressin-releasing magnocellular neurosecretory cells: Journal of Neuroendocrinology 33(11), 2021. doi: 10.1111/jne.13048.

Bruno Siqueira Mietto, Priya Jhelum, Katrin Schulz, Samuel David. Schwann cells provide iron to axonal mitochondria and its role in nerve regeneration: Journal of Neuroscience 41(34): 7300-7313, 2021. doi: 10.1523/JNEUROSCI.0900-21.2021.

Blandine Ponroy Bally, Keith Kazuo Murai. Astrocytes in Down Syndrome Across the Lifespan: Frontiers in Cellular Neuroscience 15, 2021. doi: 10.3389/fncel.2021.702685.

Qian Ren, Yong S. Rao. The exit of axons and glial membrane from the developing Drosophila retina requires integrins: Molecular Brain 15(1), 2022. doi: 10.1186/s13041-021-00888-2.

Reza Abbas Farishta, Charlene L. Yang, Reza Farivar. Blur Representation in the Amblyopic Visual System Using Natural and Synthetic Images: Investigative Ophthalmology and Visual Science 63(1), 2022. doi: 10.1167/iovs.63.1.3.

Xi Wang, Alex S. Baldwin, Robert F. Hess. Balanced binocular inputs support superior stereopsis: Investigative Ophthalmology and Visual Science 62(12), 2021. doi: 10.1167/iovs.62.12.10.

Hua Chun Sun, David G. St-Amand, Curtis L. Baker, Frederick A.A. Kingdom. Visual perception of texture regularity: Conjoint measurements and a wavelet response-distribution model: PLoS Computational Biology 17(10), 2021. doi: 10.1371/JOURNAL.PCBI.1008802.

Xi Wang, Meng Liao, Yutong Song, Longqian Liu, Alexandre Reynaud. Delayed Correction for Extrapolation in Amblyopia: Investigative Ophthalmology and Visual Science 62(15), 2021. doi: 10.1167/iovs.62.15.20.

Sara Ahmed, Diana Zidarov, Owis Eilayyan, Regina Visca. Prospective application of implementation science theories and frameworks to inform use of PROMs in routine clinical care within an integrated pain network: Quality of Life Research 30(11): 3035-3047, 2021. doi: 10.1007/s11136-020-02600-8.

Sylvie D. Lambert, Jane A. McCusker, Éric Belzile, Mark J. Yaffe, Chidinma Ihejirika, Julie Anne Richardson, Susan J. Bartlett. Using confirmatory factor analysis and Rasch analysis to examine the dimensionality of The Patient Assessment of Care for Chronic Illness Care (PACIC): Quality of Life Research 30(5): 1503-1512, 2021. doi: 10.1007/s11136-020-02750-9.

Nikki Ow, Maryam Mozafarinia, Nancy E. Mayo. Quality of life measures in pediatric multiple sclerosis: a systematic review and meta-analysis: Developmental Medicine and Child Neurology 63(9): 1051-1058, 2021. doi: 10.1111/dmcn.14870.

Catherine Duclos, Danielle Nadin, Yacine Mahdid, Vijay C. Tarnal, Paul Picton, Giancarlo Vanini, Goodarz Golmirzaie, Ellen L. Janke, Michael S. Avidan, Max B. Kelz, George A. Mashour, Stefanie Blain-Moraes. Brain network motifs are markers of loss and recovery of consciousness: Scientific Reports 11(1), 2021. doi: 10.1038/s41598-021-83482-9.

Alain Ptito, Linda Papa, Kenton W.Md Gregory, Robert L. Folmer, William C. Walker, Vivek Prabhakaran, Rima Wardini, Kimberly L. Skinner, Michael R. Yochelson. A Prospective, Multicenter Study to Assess the Safety and Efficacy of Translingual Neurostimulation Plus Physical Therapy for the Treatment of a Chronic Balance Deficit Due to Mild-to-Moderate Traumatic Brain Injury: Neuromodulation 24(8): 1412-1421, 2021. doi: 10.1111/ner.13159.

Bill Qi, Sonia Boscenco, Janani Ramamurthy, Yannis J. Trakadis. Transcriptomics and machine learning to advance schizophrenia genetics: A case-control study using post-mortem brain data: Computer Methods and Programs in Biomedicine 214, 2022. doi: 10.1016/j.cmpb.2021.106590.

Valérie D'Amour-Horvat, Sylvia Maria Leonarda Cox, Alain A. Dagher, Theodore T. Kolivakis, Natalia Jaworska, Marco Leyton. Cocaine cue-induced mesocorticolimbic activation in cocaine users: Effects of personality traits, lifetime drug use, and acute stimulant ingestion: Addiction Biology 27(1), 2022. doi: 10.1111/adb.13094.

Philippe Albouy, Zaida Escila Martínez-Moreno, Roxane S. Hoyer, Robert J. Zatorre, Sylvain Baillet. Supramodality of neural entrainment: Rhythmic visual stimulation causally enhances auditory working memory performance: Science Advances 8(8), 2022. doi: 10.1126/sciadv.abj9782.

Christina Caccese, Sherri Lee Jones, Mrinalini Ramesh, Ally Yu, Marie Brossard-Racine, Tuong Vi B. Nguyen. Role of testosterone: cortisol ratio in age- and sex-specific cortico-hippocampal development and cognitive performance: Journal of Developmental Origins of Health and Disease 13(1): 28-38, 2022. doi: 10.1017/S204017442100012X.





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