RI-MUHC ANNUAL REPORT 2023
YEAR IN REVIEW
INJURY REPAIR RECOVERY (IRR) PROGRAM
RESEARCH HIGHLIGHTS
Taking opioids at home after surgery: More harms than benefits
A study co-led by Julio Fiore Jr., PhD, and Liane Feldman, MD, researchers in the Injury Repair Recovery (IRR) Program at the Research Institute of the McGill University Health Centre (RI-MUHC), concludes that prescribing opioid analgesics at discharge after surgery does not reduce postoperative pain and increases the risk of adverse events. The study results indicate that prescribing opioids to manage postoperative pain after discharge is not only unnecessary, but harmful in many surgical settings. These findings, published in The Lancet, fill a critical gap in knowledge about how pain should be managed at home after surgery.
Multimodal prehabilitation for patients awaiting open abdominal aortic aneurysm repair
The PREEHAB Trial, an international clinical trial funded by the CIHR and led by Dr. Heather Gill, a scientist in the IRR Program, is investigating whether a multidisciplinary pre-operative program that involves exercise training, nutritional advice and supplementation, and psychosocial support will reduce complications following surgery. This program should decrease complications and speed up a patient's recovery after surgery. It is also a way for patients to take ownership of their disease and play an active role in their health care journey. The benefits from this program will go beyond the pre-operative time frame, as the habits and knowledge gained will improve their health over their lifetime. This study will also assess the economic impact and cost of a program like this.
Treatment of fibrosis in scleroderma
IRR Program researcher Anie Philip, PhD, and her McGill colleague Dieter Reinhardt, PhD, received a seed fund grant from the McGill Interdisciplinary Initiative in Infection and Immunity (MI4) to study scleroderma (systemic sclerosis), a chronic connective tissue disease characterized by fibrosis of the skin and internal organs. Their main goal is to determine whether soluble CD109 released from mesenchymal stromal cells (MSCs) can reduce fibrosis in systemic sclerosis animal models and skin biopsies of systemic sclerosis patients.
Selected IRR Program news links
- Taking opioids at home after surgery: More harms than benefits
- The 2023 McGill Clinical Innovation Competition results are out
- CQDM funds a collaborative research project between the RI-MUHC and Divocco AI
- Perception is everything when it comes to the heart
- René St-Arnaud honoured by the American Society for Bone and Mineral Research
- MORE IRR Program news
SELECTED PUBLICATIONS
Li, Li, Kai Sheng, Matthew Mannarino, Peter Jarzem, Hosni Cherif, and Lisbet Haglund. 2022. "o-Vanillin Modulates Cell Phenotype and Extracellular Vesicles of Human Mesenchymal Stem Cells and Intervertebral Disc Cells" Cells 11, no. 22: 3589. doi: 10.3390/cells11223589
Alan N. Barkun and Ali A. Alali. What Is the Current Role of an Over-the-Scope Clip Used as First-Line Endoscopic Hemostasis in Patients With Nonvariceal Upper Gastrointestinal Bleeding? Annals of Internal Medicine: doi: 10.7326/M23-0449
Feldman Liane S, Lee Lawrence. Appendicoliths, Antibiotic Treatment Failure, and Appendectomy—Is the Glass Half Full or Half Empty? JAMA Surg. 2022; 157(3): e216901. doi: 10.1001/jamasurg.2021.6901
Julio F Fiore, Charbel El-Kefraoui, Marc-Aurele Chay, Philip Nguyen-Powanda, Uyen Do, Ghadeer Olleik, Fateme Rajabiyazdi, Araz Kouyoumdjian, Alexa Derksen, Tara Landry, Alexandre Amar-Zifkin, Amy Bergeron, Agnihotram V Ramanakumar, Marc Martel, Lawrence Lee, Gabriele Baldini, Liane S Feldman. Opioid versus opioid-free analgesia after surgical discharge: a systematic review and meta-analysis of randomised trials. The Lancet, Volume 399, Issue 10343, 2022, Pages 2280-2293, ISSN 0140-6736. doi: 10.1016/S0140-6736(22)00582-7
Dahan-Oliel N, van Bosse H, Darsaklis VB, et al. Epidemiology, aetiology, interventions and genomics in children with arthrogryposis multiplex congenita: protocol for a multisite registry. BMJ Open 2022;12: e060591. doi: 10.1136/bmjopen-2021-060591
Lee Lawrence, McLemore Elisabeth, Rashidi Laila. Same-Day Discharge After Minimally Invasive Colectomy. JAMA Surg. 2022;157(11):1059–1060. doi: 10.1001/jamasurg.2022.4123
Wennberg Erika, Windle Sarah B, Filion Kristian B, et al. Interventions for physician prescribers of opioids for chronic non-cancer pain: protocol for an overview of systematic reviews. BMJ Open 2022;12: e060964. doi: 10.1136/bmjopen-2022-060964
Zhou Shufeng, Amani Hassan, Tenzin Kungyal, Sebastien Tabariès, José Luis Ramírez García Luna, Peter M. Siegel, and Anie Philip. 2022. "CD109 Is a Critical Determinant of EGFR Expression and Signaling, and Tumorigenicity in Squamous Cell Carcinoma Cells" Cancers 14, no. 15: 3672. doi: 10.3390/cancers14153672
Hyeree Park, Showan N. Nazhat, Derek H. Rosenzweig. Mechanical activation drives tenogenic differentiation of human mesenchymal stem cells in aligned dense collagen hydrogels. Biomaterials, Volume 286, 2022, 121606, ISSN 0142-9612. doi: 10.1016/j.biomaterials.2022.121606
Addab, S., Hamdy, R., Thorstad, K., Le May, S., & Tsimicalis, A. (2022). Use of virtual reality in managing paediatric procedural pain and anxiety: An integrative literature review. Journal of Clinical Nursing, 31, 3032–3059. doi: 10.1111/jocn.16217
Deeken Friederike, Sánchez Alba, Rapp Michael A, et al. Outcomes of a Delirium Prevention Program in Older Persons After Elective Surgery: A Stepped-Wedge Cluster Randomized Clinical Trial. JAMA Surg. 2022;157(2):e216370. doi: 10.1001/jamasurg.2021.6370
Sean D. Jeffries, Zheyan Tu, Hongtao Xu, Robert Harutyunyan, Thomas M. Hemmerling. Use of hand sanitiser as a potential substitution for nonsterile gloves in reducing carbon emissions. British Journal of Anaesthesia, Volume 131, Issue 1, 2023, Pages e22-e25, ISSN 0007-0912. doi: 10.1016/j.bja.2023.03.029
