RI-MUHC ANNUAL REPORT 2024
SELECTED HIGH-IMPACT PUBLICATIONS
- BRAIN REPAIR AND INTEGRATIVE NEUROSCIENCE (BRaIN) PROGRAM
- CANCER RESEARCH PROGRAM (CRP)
- CARDIOVASCULAR HEALTH ACROSS THE LIFESPAN (CHAL) PROGRAM
- CHILD HEALTH AND HUMAN DEVELOPMENT (CHHD) PROGRAM
- INFECTIOUS DISEASES AND IMMUNITY IN GLOBAL HEALTH (IDIGH) PROGRAM
- METABOLIC DISORDERS AND COMPLICATIONS (MeDiC) PROGRAM
- SURGICAL AND INTERVENTIONAL SCIENCES (SIS) PROGRAM
- TRANSLATIONAL RESEARCH IN RESPIRATORY DISEASES (RESP) PROGRAM
BRAIN REPAIR AND INTEGRATIVE NEUROSCIENCE (BRaIN) PROGRAM
Meishan Ai, Timothy P Morris, Adrián Noriega de la Colina, Nagashree Thovinakere, Jennifer Tremblay-Mercier, Sylvia Villeneuve, Charles H Hillman, Arthur F Kramer, Maiya R. Geddes. Midlife physical activity engagement is associated with later-life brain health. Neurobiology of Aging 134(0): 146-159, 2024: 85179825723: doi : 10.1016/j.neurobiolaging.2023.11.004
Clara R Freeman, Thomas M Olino, Elise B Barbeau, Anna Weinberg, Xiaoqian Jenny Chai. Family History of Depression and Neural Reward Sensitivity: Findings From the Adolescent Brain Cognitive Development Study. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging 8(6): 620-629, 2023: 85148352372: doi: 10.1016/j.bpsc.2022.09.015
Angela L Genge, Leonard H van den Berg, Glen Frick, Steve S W Han, Cori Abikoff, Adam Simmons, Qun Lin, Kaushik Patra, Erik Kupperman, James D Berry. Efficacy and Safety of Ravulizumab, a Complement C5 Inhibitor, in Adults with Amyotrophic Lateral Sclerosis: A Randomized Clinical Trial. JAMA Neurology 80(10): 1089-1097, 2023: 85172308705: doi: 10.1001/jamaneurol.2023.2851
Tim König, Heidi May McBride. Mitochondrial-derived vesicles in metabolism, disease, and aging. Cell Metabolism 36(1): 21-35, 2024: 85181764571: doi: 10.1016/j.cmet.2023.11.014
John D Lewis, Vladimir S Fonov, Donald Louis Collins. Bloody noise: The impact of blood-flow artifacts on registration. Human Brain Mapping 44(14): 4914-4926, 2023: 85166439143: doi: 10.1002/hbm.26426
Zila Martínez-Lozada, William Todd Farmer, Alexandra L Schober, Elizabeth N Krizman, Michael B Robinson, Keith Kazuo Murai. Cooperative and competitive regulation of the astrocytic transcriptome by neurons and endothelial cells: Impact on astrocyte maturation. Journal of Neurochemistry 167(1): 52-75, 2023: 85166506408: doi: 10.1111/jnc.15908
Franziska Mudlaff, Aparna Suvrathan. KIF2C and receptor trafficking: Cerebellar synapses show the way. Journal of Physiology 601(17): 3689-3690, 2023: 85167711896: doi: 10.1113/JP285221
Blake Aaron Richards, Konrad P Kording. The study of plasticity has always been about gradients. Journal of Physiology 601(15): 3141-3149, 2023: 85153215381: doi: 10.1113/JP282747
Fari Ryan, Isaac Francos-Quijorna, Gerard Hernandez Mir, Catharine Aquino, Ralph Schlapbach, Elizabeth J. Bradbury, Samuel David. Tlr4 Deletion Modulates Cytokine and Extracellular Matrix Expression in Chronic Spinal Cord Injury, Leading to Improved Secondary Damage and Functional Recovery. Journal of Neuroscience 44(6): 0, 2024: 85184614339: doi: 10.1523/JNEUROSCI.0778-23.2023
Sandra Salgado-Mozo, Zahra S Thirouin, Joshua C Wyrosdic, Ubaldo García-Hernández, Charles W Bourque. NaX Channel Is a Physiological [Na+] Detector in Oxytocin- and Vasopressin-Releasing Magnocellular Neurosecretory Cells of the Rat Supraoptic Nucleus. Journal of Neuroscience 43(49): 8306-8316, 2023: 85179496636: doi : 10.1523/JNEUROSCI.1203-23.2023
Hovy Ho-Wai Wong, Alanna J Watt, P Jesper Sjöström. Synapse-specific burst coding sustained by local axonal translation. Neuron. 2024 Jan 17; 112(2): 264-276.e6. doi: 10.1016/j.neuron.2023.10.011
Eric Yu, Lynne Krohn, Jennifer A Ruskey, Farnaz Asayesh, Dan V Spiegelman, Zalak Shah, Ruth Chia, Isabelle Arnulf, Michele T Hu, Jacques Yves Montplaisir, Jean François Gagnon, Alex Désautels, Yves A Dauvilliers, Gian Luigi Gigli, Mariasrosaria C Valente, Francesco Janes, Andrea Bernardini, Birgit Högl, Ambra Stefani, Abubaker Ibrahim, Anna Heidbreder, Karel Sonka, Petr Dusek, David Kemlink, Wolfgang Oertel, Annette Janzen, Giuseppe Plazzi, Elena Antelmi, Michela Figorilli, Monica Puligheddu, Brit Mollenhauer, Claudia Trenkwalder, Friederike Sixel-Döring, Valérie Cochen De Cock, Luigi Ferini-Strambi, Femke Dijkstra, Mineke Viaene, Beatriz Abril, Bradley F Boeve, Guy A Rouleau, Ronald B Postuma; International LBD Genomics Consortium; Sonja W Scholz, Ziv Gan-Or. HLA in isolated REM sleep behavior disorder and Lewy body dementia. Annals of Clinical and Translational Neurology 10(9): 1682-1687, 2023: 85164501065: doi: 10.1002/acn3.51841
Learn what’s happening in BRaIN Program news
CANCER RESEARCH PROGRAM (CRP)
Yen-I Chen, Anand Sahai, Gianfranco Donatelli, Eric Lam, Nauzer Forbes, Jeffrey Mosko, Sarto C Paquin, Fergal Donnellan, Avijit Chatterjee, Jennifer Telford, Corey Miller, Etienne Desilets, Gurpal Sandha, Sana Kenshil, Rachid Mohamed, Gary May, Ian Gan, Jeffrey Barkun, Natalia Calo, Abrar Nawawi, Gad Friedman, Albert Cohen, Thibaut Maniere, Prosanto Chaudhury, Peter Metrakos, George Zogopoulos, Ali Bessissow, Jad Abou Khalil, Vicky Baffis, Kevin Waschke, Josee Parent, Constantine Soulellis, Mouen Khashab, Rastisla Kunda, Olivia Geraci, Myriam Martel, Kevin Schwartzman, Julio F Fiore Jr., Elham Rahme, Alan Barkun. Endoscopic Ultrasound-Guided Biliary Drainage of First Intent With a Lumen-Apposing Metal Stent vs Endoscopic Retrograde Cholangiopancreatography in Malignant Distal Biliary Obstruction: A Multicenter Randomized Controlled Study (ELEMENT Trial). Gastroenterology. 2023 Nov; 165(5): 1249-1261.e5. doi: 10.1053/j.gastro.2023.07.024
Walead Ebrahimizadeh, Karl-Philippe Guérard, Shaghayegh Rouzbeh, Eleonora Scarlata, Fadi Brimo, Palak G Patel, Tamara Jamaspishvili, Lucie Hamel, Armen G. Aprikian, Anna Y Lee, David M Berman, John M S Bartlett, Simone Chevalier, Jacques Lapointe. A DNA copy number alteration classifier as a prognostic tool for prostate cancer patients. Br J Cancer. 2023 Jun; 128(12): 2165-2174. doi: 10.1038/s41416-023-02236-8
Sarah Tadhg Ferrier, Thupten Tsering, Nader Sadeghi, Anthony Zeitouni, Julia V Burnier. Blood and saliva-derived ctDNA is a marker of residual disease after treatment and correlates with recurrence in human papillomavirus-associated head and neck cancer. Cancer Med. 2023 Aug; 12(15): 15777-15787. doi: 10.1002/cam4.6191
Jennifer Gantchev, Julia Messina-Pacheco, Amelia Martínez Villarreal, Brandon Ramchatesingh, Philippe Lefrançois, Pingxing Xie, Laetitia Amar, Hong Hao Xu, Keerthenan Raveendra, Daniel Sikorski, Daniel Josue Guerra Ordaz, Raman Preet Kaur Gill, Marine Lambert, Ivan V Litvinov. Ectopically Expressed Meiosis-Specific Cancer Testis Antigen HORMAD1 Promotes Genomic Instability in Squamous Cell Carcinomas. Cells. 2023 Jun 14; 12(12): 1627. doi: 10.3390/cells12121627
Yi He, Marie-Anne Goyette, Jennifer Chapelle, Nadia Boufaied, Jalal Al Rahbani, Maribel Schonewolff, Eric I Danek, William J Muller, David P Labbé, Jean-François Côté, Nathalie Lamarche-Vane. CdGAP is a talin-binding protein and a target of TGF-β signaling that promotes HER2-positive breast cancer growth and metastasis. Cell Rep. 2023 Aug 29; 42(8): 112936. doi: 10.1016/j.celrep.2023.112936
Felix K F Kommoss, Anne-Sophie Chong, Anne-Laure Chong, Elke Pfaff, David T W Jones, Laura S. Hiemcke-Jiwa, Lennart A Kester, Uta Flucke, Manfred Gessler, Daniel Schrimpf, Felix Sahm, Blaise A Clarke, Colin J R Stewart, Yemin Wang, C Blake Gilks, Friedrich Kommoss, David G Huntsman, Ulrich Schüller, Christian Koelsche, W Glenn McCluggage, Andreas von Deimling, William D Foulkes. Genomic characterization of DICER1-associated neoplasms uncovers molecular classes. Nat Commun. 2023 Mar 25; 14(1): 1677. doi: 10.1038/s41467-023-37092-w
Ronald Kool, Gautier Marcq, Rodney H Breau, Peter C. Black, Bobby Shayegan, Michael Kim, Ionut Busca, Hamidreza Abdi, Mark T Dawidek, Michael Uy, Gagan Fervaha, Fabio L Cury, Nimira S Alimohamed, Jonathan I Izawa, Claudio Jeldres, Ricardo Rendon, D Robert Siemens, Girish S Kulkarni, Wassim Kassouf. Radiation-based Therapy for Muscle-invasive Bladder Cancer: Contemporary Outcomes Across Tertiary Centers. Eur Urol Oncol. 2023 Dec; 6(6): 597-603. doi: 10.1016/j.euo.2023.03.004
Haley M Patrick, John Kildea. More than one way to skin a dose volume: the impact of dose-surface map calculation approach on study reproducibility. Phys Med Biol. 2024 Jan 22; 69(2). doi: 10.1088/1361-6560/ad19ef
Joan Miguel Romero, Emma Titmuss, Yifan Wang, James Vafiadis, Alain Pacis, Gun Ho Jang, Amy Zhang, Bryn Golesworthy, Tatiana Lenko, Laura M Williamson, Barbara Grünwald, Grainne M O’Kane, Steven J M Jones, Marco A Marra, Julie M. Wilson, Steven Gallinger, Janessa Laskin, George Zogopoulos. Chemokine expression predicts T cell-inflammation and improved survival with checkpoint inhibition across solid cancers. NPJ Precis Oncol. 2023 Aug 9; 7(1): 73. doi: 10.1038/s41698-023-00428-2
Jennifer A Silver, Nathaniel Bouganim, Keith Richardson, Melissa Henry, Marco A. Mascarella, José Ramirez-GarciaLuna, Nahid Golabi, Alex M Mlynarek, Anthony Zeitouni, Michael P Hier, Derin Caglar, Khashayar Esfahani, Nader Sadeghi. Quality of Life After Neoadjuvant Chemotherapy and Transoral Robotic Surgery for Oropharynx Cancer. JAMA Otolaryngol Head Neck Surg. 2024 Jan 1; 150(1): 65-74. doi: 10.1001/jamaoto.2023.3781
Xin Su, Ariane Brassard, Alexandra Bartolomucci, Iqraa Dhoparee-Doomah, Qian Qiu, Thupten Tsering, Ramin Rohanizadeh, Olivia Koufos, Betty Giannias, France Bourdeau, Lixuan Feng, Julia Messina-Pacheco, Sabrina Leo, Veena Sangwan, Daniela Quail, James Tankel, Jonathan Spicer, Julia Valdemarin Burnier, Swneke Donovan Bailey, Lorenzo Ferri, Jonathan Cools-Lartigue. Tumour extracellular vesicles induce neutrophil extracellular traps to promote lymph node metastasis. J Extracell Vesicles. 2023 Aug; 12(8): e12341. doi: 10.1002/jev2.12341
Gang Yan, Meiou Dai, Sophie Poulet, Ni Wang, Julien Boudreault, Girija Daliah, Suhad Ali, Jean-Jacques Lebrun. Combined in vitro/in vivo genome-wide CRISPR screens in triple negative breast cancer identify cancer stemness regulators in paclitaxel resistance. Oncogenesis. 2023 Nov 6; 12(1): 51. doi: 10.1038/s41389-023-00497-9
Learn what’s happening in Cancer Research Program news
CARDIOVASCULAR HEALTH ACROSS THE LIFESPAN (CHAL) PROGRAM
Jason G Andrade, Marc W. Deyell, Laurent Macle, George A Wells, Matthew Bennett, Vidal Essebag, Jean Champagne, Jean‑Francois Roux, Derek Yung, Allan Skanes, Yaariv Khaykin, Carlos Morillo, Umjeet Jolly, Paul Novak, Evan Lockwood, Guy Amit, Paul Angaran, John Sapp, Stephan Wardell, Sandra Lauck, Julia Cadrin‑Tourigny, Simon Kochhäuser, Atul Verma. Progression of Atrial Fibrillation after Cryoablation or Drug Therapy. New England Journal of Medicine 388: 105-16, 2023: doi: 10.1056/NEJMoa2212540
James M Brophy, Lyne Nadeau. Beta-Blockers, Digoxin, or Both Following an Incident Diagnosis of Atrial Fibrillation: A Prospective Cohort Study. Canadian Journal of Cardiology 39(11): 1587-1593, 2023: 85171977459: doi: 10.1016/j.cjca.2023.06.009
Karina Gasbarrino, Huaein Zheng, Stella S Daskalopoulou. Circulating Sex-Specific Markers of Plaque Instability in Women and Men With Severe Carotid Atherosclerosis. Stroke 55(2): 269-277, 2024. doi: 10.1161/STROKEAHA.123.044840
Elizabeth Hillier, Jason Covone, Kady Fischer, Hao Yu Chen, Tarik Hafyane, Matthias G Friedrich. Microvascular Dysfunction as a Possible Link Between Heart Failure and Cognitive Dysfunction. Circulation Heart Failure 2023 Sep 26:e010117. doi: 10.1161/CIRCHEARTFAILURE.122.010117
Amanpreet Kaur, Adriana Angarita Fonseca, Rikki Lissaman, Hassan Behlouli, Natasha M Rajah, Louise Pilote. Sex Differences in the Association of Age at Hypertension Diagnosis With Brain Structure. Hypertension. 2023 Dec 19: doi: 10.1161/HYPERTENSIONAHA.123.22180
Judy Luu, Natalie Dayan. The Duality of Screening Mammography: Advancing Women's Cardiovascular Health. Canadian Journal of Cardiology. 2023 Sep 23: S0828-282X(23)01737-3: doi: 10.1016/j.cjca.2023.09.022
Augusto Cesar I Montezano, Lívia De Lucca Camargo, Sheon Mary, Karla Bianca Neves, Francisco J Rios, Ross Stein, Rhéure Alves Moreira Lopes, Wendy Beattie, Jacqueline Thomson, Vanessa Herder, Agnieszka M Szemiel, Steven McFarlane, Massimo Palmarini, Rhian Touyz. SARS-CoV-2 spike protein induces endothelial inflammation via ACE2 independently of viral replication. Scientific Reports 13(1): 0, 2023: 85168912123: doi: 10.1038/s41598-023-41115-3
Harry Moroz, Yue Li, Ariane J Marelli. hART: Deep learning-informed lifespan heart failure risk trajectories. International Journal of Medical Informatics 185(0): 0, 2024: 85185555134: doi: 10.1016/j.ijmedinf.2024.105384
Girish M Nair, David Hugh Birnie, Pablo Balbuena Nery, Calum J Redpath, Jean François Sarrazin, Jean François Roux, Ratika Parkash, Martin Louis Bernier, Laurence D Sterns, John Lewis Sapp, Paul G Novak, George D Veenhuyzen, Carlos A Morillo, Sheldon M Singh, Mouhammad M Sadek, Andres Klein, Marcio Stumer, Vijay S Chauhan, Paul Angaran, Martin S Green, Jordan Bernick, George A Wells, Vidal Essebag. Standard vs Augmented Ablation of Paroxysmal Atrial Fibrillation for Reduction of Atrial Fibrillation Recurrence: The AWARE Randomized Clinical Trial. JAMA Cardiology 8(5): 475-483, 2023: 85159281251: doi: 10.1001/jamacardio.2023.0212
Suzie Ouellet, Sandrine Hamel, Camille Simard, Maral Koolian, Antony Robert, Karen Wou, Stephanie Lam, Amal Bessissow, Sarah St-Georges, Vicky Tagalakis, Alexandra De Pokomandy, Linda S Snell, Ningzi Sun, Isabelle Malhamé. Exploring pregnant individuals’ counseling needs regarding urgent imaging to rule out pulmonary embolism. Research and Practice in Thrombosis and Haemostasis 8(2): 0, 2024: 85187178717: doi: 10.1016/j.rpth.2024.102317
Abhinav Sharma, Silvio E Inzucchi, Jeffrey Moore Testani, Anne Pernille Ofstad, David H Fitchett, Michaela Mattheus, Subodh G Verma, Faiez Zannad, Christoph Wanner, Bettina Johanna Kraus. Kidney and heart failure events are bidirectionally associated in patients with type 2 diabetes and cardiovascular disease. ESC Heart Failure 11(2): 737-747, 2024: 85180699892: doi: 10.1002/ehf2.14601
Ukah Vivian Ukah, Robert W Platt, Natalie Auger, Sarka Lisonkova, Joel G Ray, Isabelle Malhamé, Aimina Ayoub, Darine El-Chaâr, Natalie Dayan. Risk of recurrent severe maternal morbidity: A population-based study. American Journal of Obstetrics and Gynecology 2023 Jun 8:S0002-9378(23)00382-4. doi: 10.1016/j.ajog.2023.06.010
Learn what’s happening in CHAL Program news
CHILD HEALTH AND HUMAN DEVELOPMENT (CHHD) PROGRAM
William G Bauer, David Watkins, Caitlin A Zacharias, Brian M Gilfix, David S Rosenblatt. Growth requirement for methionine in human melanoma-derived cell lines with different levels of MMACHC expression and methylation. Molecular Genetics and Metabolism 141(1): 0, 2024: 85180086038: doi: 10.1016/j.ymgme.2023.108111
Kaitlyn Easson, May Ahmed Khairy, Charles V Rohlicek, Guillaume Gilbert, Annette Majnemer, Kim Anh Nguyen, Thuy Mai Luu, Élise Couture, Anne Monique Nuyt, Sean C L Deoni, Maxime Descoteaux, Marie Brossard-Racine. White matter microstructure is differently associated with executive functioning in youth born with congenital heart disease and youth born preterm. Brain and Behavior 13(12): 0, 2023: 85177604866: doi: 10.1002/brb3.3308
Alaa T Ibrahim, Afiqah Yusuf, Hannah R Pickard, Pamela J Dixon, Andy J Shih, Stephanie Yoshiko Shire, Andrew R Pickles, M. Elsabbagh. Evaluation of an adapted virtual training for master trainers of the WHO Caregiver Skills Training Program during the COVID-19 pandemic. Autism 28(2): 510-514, 2024: 85161626801: doi: 10.1177/13623613231173758
Hormoz Nassiri Kigloo, Rayan Itani, Tina C Montreuil, Ido Feferkorn, Jason Raina, Togas Tulandi, Fady W Mansour, Srinivasan Krishnamurthy, Eva Suarthana. Endometriosis, chronic pain, anxiety, and depression: A retrospective study among 12 million women. Journal of Affective Disorders 346(0): 260-265, 2024: 85178650268: doi: 10.1016/j.jad.2023.11.034
Alejandra Martinez-Valderrama, Kenneth A Myers. Electroencephalographic Patterns in Pediatric Patients With Multisystem Inflammatory Syndrome in Children and Coronavirus Disease 2019 Coinfection. Pediatric Neurology 149(0): 114-119, 2023: 85174465061: doi: 10.1016/j.pediatrneurol.2023.09.014
Olivia Petrone, Steven Serafini, Bess Yi Kun Yu, Valeriy V Filonenko, Ivan Tarasovych Gout, C M O'Flaherty. Changes of the Protein CoAlation Pattern in Response to Oxidative Stress and Capacitation in Human Spermatozoa. International Journal of Molecular Sciences 24(15): 0, 2023: 85167771015: doi: 10.3390/ijms241512526
Karolina Popławska, Anne Griffiths, Renee T Temme, Darryl J Adamko, Keith R Nykamp, Adam J Shapiro. Deletions in DNAL1 Cause Primary Ciliary Dyskinesia Across North American Indigenous Populations. Journal of Pediatrics 261(0): 0, 2023: 85163003332: doi: 10.1016/j.jpeds.2023.01.023
Wissam Shalish, Guilherme Mendes Sant'Anna. Optimal timing of extubation in preterm infants. Seminars in Fetal and Neonatal Medicine 28(5): 0, 2023: 85178396451: doi: 10.1016/j.siny.2023.101489
Elizabeth F Teel, Christophe Alarie, Bonnie R Swaine, Nathan E Cook, Grant L Iverson, Isabelle J Gagnon. An At-Home, Virtually Administered Graded Exertion Protocol for Use in Concussion Management: Preliminary Evaluation of Safety and Feasibility for Determining Clearance to Return to High-Intensity Exercise in Healthy Youth and Children With Subacute Concu. Journal of Neurotrauma 40: 1730-1742, 2023: 85168363325: doi: 10.1089/neu.2022.0370
Monica Vaillancourt, Elise Mok, Jennifer Frei, Kaberi Dasgupta, Elham Rahme, Lorraine E Bell, Deborah D Da Costa, Meranda M Nakhla. Qualitative study exploring the perspectives of emerging adults with type 1 diabetes after transfer to adult care from a paediatric diabetes centre in Montreal, Canada. BMJ Open 13(10): 0, 2023: 85175219627: doi: 10.1136/bmjopen-2023-076524
Seline Y Vancolen, Taghreed A Ayash, Marie Julie Allard, Guillaume Sébire. Sex-Specific Dysconnective Brain Injuries and Neuropsychiatric Conditions such as Autism Spectrum Disorder Caused by Group B Streptococcus-Induced Chorioamnionitis. International Journal of Molecular Sciences 24(18): 0, 2023: 85172767641: doi: 10.3390/ijms241814090
Pia Wintermark, Anie Lapointe, Robin Heise Steinhorn, Emmanouil Rampakakis, Jürgen Burhenne, Andreas Daniel Meid, Gzona Bajraktari-Sylejmani, May Ahmed Khairy, Gabriel Altit, Marie Therese Adamo, Alishia Poccia, Guillaume Gilbert, Christine Saint-Martin, . Feasibility and Safety of Sildenafil to Repair Brain Injury Secondary to Birth Asphyxia (SANE-01): A Randomized, Double-blind, Placebo-controlled Phase Ib Clinical Trial. Journal of Pediatrics 266(0): 0, 2024: 85182563206: doi: 10.1016/j.jpeds.2023.113879
Learn what’s happening in CHHD Program news
INFECTIOUS DISEASES AND IMMUNITY IN GLOBAL HEALTH (IDIGH) PROGRAM
Tho-Alfakar Al-Aubodah, Lamine Aoudjit, Giuseppe Pascale, Maneka A Perinpanayagam, David Langlais, Martin Bitzan, Susan M Samuel, Ciriaco A Piccirillo, Tomoko Takano (2023). The extrafollicular B cell response is a hallmark of childhood idiopathic nephrotic syndrome. Nature communications, vol. 14, p. 7682. doi: 10.1038/s41467-023-43504-8
Jacob Bigio, Emily L-H MacLean, Rishav Das, Giorgia Sulis, Mikashmi Kohli, Sarah Berhane, Jacqueline Dinnes, Jonathan J Deeks, Lukas E Brümmer, Claudia M Denkinger, Madhukar Pai (2023). Accuracy of package inserts of SARS-CoV-2 rapid antigen tests: a secondary analysis of manufacturer versus systematic review data. The Lancet. Microbe, vol. 4, p. e875-e882. doi: 10.1016/S2666-5247(23)00222-7
Antonios Douros, Zharmaine Ante, Carlo A Fallone, Laurent Azoulay, Christel Renoux, Samy Suissa, Paul Brassard (2024). Clinically apparent Helicobacter pylori infection and the risk of incident Alzheimer's disease: A population-based nested case-control study. Alzheimer's & dementia: the journal of the Alzheimer's Association, vol. 20, p. 76-724. doi: 10.1002/alz.13561
Shannon C Duffy, Ben Marais, Vivek Kapur, Marcel A Behr, (2024). Zoonotic tuberculosis in the 21st century. The Lancet. Infectious diseases, vol. 24, p. 339-341. doi: 10.1016/S1473-3099(24)00059-8
Jonah H Gorodensky, Sasha Bernatsky, Waqqas Afif, Yvan St-Pierre, Kristian B Filion, Évelyne Vinet (2024). Serious Infections in Offspring Exposed in Utero to Vedolizumab. Inflammatory bowel diseases, vol. 30, p. 496-498. doi: 10.1093/ibd/izad079
Ryan Hanula, Émilie Bortolussi-Courval, Arielle Mendel, Brian J Ward, Todd C Lee, Emily G McDonald (2024). Evaluation of Oseltamivir Used to Prevent Hospitalization in Outpatients With Influenza: A Systematic Review and Meta-analysis. JAMA internal medicine, vol. 84, p. 8-27. doi: 10.1001/jamainternmed.2023.0699
Karla P Martinez, Najla Gasmi, Célia Jeronimo, Natalia Klimova, François Robert, Bernard Turcotte (2024). Yeast zinc cluster transcription factors involved in the switch from fermentation to respiration show interdependency for DNA binding revealing a novel type of DNA recognition. Nucleic acids research, vol. 52, p. 2242-2259. doi: 10.1093/nar/gkad1185
Lauren Perlman, Sofianne Gabrielli, Ann E Clarke, Luca Delli Colli, Marina Delli Colli, Judy Morris, Jocelyn Gravel, Rodrick Lim, Edmond S Chan, Ran D Goldman, Andrew O'Keefe, Jennifer Gerdts, Derek K Chu, Julia Upton, Elana Hochstadter, Jocelyn Moisan, Adam Bretholz, Christine McCusker, Xun Zhang, Jennifer L P Protudjer, Elissa M Abrams, Elinor Simons, Moshe Ben-Shoshan (2023). Pediatric Wheat-Induced Anaphylaxis from the Cross-Canada Anaphylaxis Registry: Clinical Characteristics and Management. The journal of allergy and clinical immunology. In practice, vol., p. 2592-2594.e. doi:0.06/j.jaip.2023.05.024
Pauline Rivière, Caitlyn Kanters, Gauthier Pellet, Alexander Ni, Marianne Hupé, Nesrine Aboulhamid, Florian Poullenot, Alain Bitton, Frank Zerbib, Peter L Lakatos, Waqqas Afif, David Laharie, Talat Bessissow (2023). Comparative Effectiveness of Ustekinumab and Anti-TNF Agent as First-Line Biological Therapy in Luminal Crohn's Disease: A Retrospective Study From 2 Referral Centers. Inflammatory bowel diseases, vol. 29, p. 923-93. doi: 10.1093/ibd/izac167
Lucie Roussel, Anne Pham-Huy, Andrea C Yu, Sunita Venkateswaran, Anna Perez, Guillaume Bourdel, Yichun Sun, Stephanya T Villavicencio, Stéphane Bernier, Yongbiao Li, Makayla Kazimerczak-Brunet, Rolan Alattar, Marc-André Déry, Adam J Shapiro, Justin Penner, Donald C Vinh. A Novel Homozygous Mutation Causing Complete TYK2 Deficiency, with Severe Respiratory Viral Infections, EBV-Driven Lymphoma, and Jamestown Canyon Viral Encephalitis. Journal of clinical immunology, vol. 43, p. 20-202. doi: 10.1007/s10875-023-01580-x
Karim Sacre, Evelyne Vinet, Christian A Pineau, Arielle Mendel, Fares Kalache, Louis-Pierre Grenier, Thao Huynh, Sasha Bernatsky (2024). N-Terminal pro-Brain Natriuretic Peptide is a biomarker for cardiovascular damage in systemic lupus erythematous: a cross-sectional study. Rheumatology (Oxford, England), vol. 63, p. 739-745. doi: 10.1093/rheumatology/kead522
Tilmann Schober, Kimberly Wong, Gaëlle DeLisle, Chelsea Caya, Nathan J Brendish, Tristan W Clark, Nandini Dendukuri, Quynh Doan, Patricia S Fontela, Genevieve C Gore, Patricia Li, Allison J McGeer, Kim Chloe Noël, Joan L Robinson, Eva Suarthana, Jesse Papenburg (2024). Clinical Outcomes of Rapid Respiratory Virus Testing in Emergency Departments: A Systematic Review and Meta-Analysis. JAMA internal medicine, vol. 84, p. 528-536. doi: 10.1001/jamainternmed.2024.0037
Learn what’s happening in IDIGH Program news
METABOLIC DISORDERS AND COMPLICATIONS (MeDiC) PROGRAM
Tho-Alfakar Al-Aubodah, Lamine Aoudjit, Giuseppe Pascale, Maneka A Perinpanayagam, David Langlais, Martin Bitzan, Susan M Samuel, Ciriaco A Piccirillo, Tomoko Takano (2023). The extrafollicular B cell response is a hallmark of childhood idiopathic nephrotic syndrome. Nature communications, vol. 14, p. 7682. doi: 10.1038/s41467-023-43504-8
Olivia Auclair, Patricia Eustachio Colombo, James Milner, Sergio A Burgos. Partial substitutions of animal with plant protein foods in Canadian diets have synergies and trade-offs among nutrition, health and climate outcomes. Nat Food. 2024 Feb; 5(2): 148-157. doi: 10.1038/s43016-024-00925-y
Juan Ballesteros, Daniel Rivas, Gustavo Duque. The Role of the Kynurenine Pathway in the Pathophysiology of Frailty, Sarcopenia, and Osteoporosis. Nutrients 15(14): 0, 2023: 85165957160: doi: 10.3390/nu15143132
Didier Brassard, Stéphanie Chevalier. Relationship between Adherence to the 2019 Canada's Food Guide Recommendations on Healthy Food Choices and Nutrient Intakes in Older Adults. Journal of Nutrition 153(9): 2699-2708, 2023: 85166667921: doi: 10.1016/j.tjnut.2023.07.005
Kaberi Dasgupta, Joseph Mussa, Anne Sophie Brazeau, Mourad Dahhou, Claudia A Sanmartin, Nancy A Ross, Elham Rahme. Associations of free sugars from solid and liquid sources with cardiovascular disease: a retrospective cohort analysis. BMC Public Health 23(1):0, 2023: 85153686864: doi: 10.1186/s12889-023-15600-3
Guy Hajj-Boutros, Vita Sonjak, Andréa Faust, Eric Hedge, Carmelo Mastrandrea, Jean-Christophe Lagacé, Philippe St-Martin, Donya Naz Divsalar, Farshid Sadeghian, Stéphanie Chevalier, Teresa Liu-Ambrose, Andrew P Blaber, Isabelle J Dionne, Simon Duchesne, Richard Hughson, Saija Kontulainen, Olga Theou, José A Morais. Impact of 14 Days of Bed Rest in Older Adults and an Exercise Countermeasure on Body Composition, Muscle Strength, and Cardiovascular Function: Canadian Space Agency Standard Measures. Gerontology. 2023; 69(11): 1284-1294. doi: 10.1159/000534063
Nazila Hassanabadi, Claudie Berger, Alexandra Papaioannou, Angela Man Wei Cheung, Elham Rahme, William D Leslie, David Goltzman, Suzanne N Morin. Geographic variation in bone mineral density and prevalent fractures in the Canadian longitudinal study on aging. Osteoporosis International 35(4): 599-611, 2024: 85178474959: doi: 10.1007/s00198-023-06975-5
Katya Loban, Elie Fadel, Peter Nugus, Antoine Przybylak-Brouillard, Heather Badenoch, Jorane-Tiana Robert, Ann Bugeja, Justin Gill, Marie-Chantal Fortin, Charo Rodriguez, Shaifali Sandal. Living kidney donors' health care needs, experiences, and perspectives across their entire donation trajectory: a semistructured, in-depth interview study. Kidney Int. 2024 Feb; 105(2): 251-258. doi: 10.1016/j.kint.2023.11.004
Melissa Rosina Pasqua, Madison Odabassian, Michael A Tsoukas, Ahmad Haidar. Participant Experiences of Low-Dose Empagliflozin Use as Adjunct Therapy to Hybrid Closed Loop: Findings From a Randomized Controlled Trial. Journal of Diabetes Science and Technology 17(6): 1448-1455, 2023: 85163027929: doi: 10.1177/19322968231176302
Lenka Schorova, Nathalie Bedard, Anouar Khayachi, Hung-Hsiang Ho, Joao Bolivar-Pedroso, Julie Huynh, Mikaela Piccirelli, Yifei Wang, Marie Plourde, Wen Luo, Esther del Cid-Pellitero, Irina Shlaifer, María José Castellanos-Montiel, Ziqi Yu, Dulce Valeria Carrillo Valenzuela, María Lacalle-Aurioles, Anita Kriz, Yihong Ye, Thomas M Durcan, Simon S Wing. USP19 deubiquitinase inactivation regulates α-synuclein ubiquitination and inhibits accumulation of Lewy body-like aggregates in mice. NPJ Parkinsons Dis. 2023 Nov 28; 9(1): 157. doi: 10.1038/s41531-023-00601-1
Estelle Tran, Oliver Karadjian, Christopher T M Chan, Emilie Trinh. Home hemodialysis technique survival: insights and challenges. BMC Nephrology 24(1): 0, 2023: 85164419147: doi: 10.1186/s12882-023-03264-5
Rui Zhang, Jiarong Li, Dunarel Badescu, Andrew C Karaplis, Ioannis Ragoussis, Richard B Kremer. PTHrP Regulates Fatty Acid Metabolism via Novel lncRNA in Breast Cancer Initiation and Progression Models. Cancers 15(15): 0, 2023: 85168285370: doi: 10.3390/cancers15153763
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SURGICAL AND INTERVENTIONAL SCIENCES (SIS) PROGRAM
Pouyan Ahangar, Jialiang Li, Leslie S Nkindi, Zohreh Mohammadrezaee, Megan E Cooke, Paul A Martineau, Michael H Weber, Elie Saade, Nima Nateghi, Derek H Rosenzweig. A Nanoporous 3D-Printed Scaffold for Local Antibiotic Delivery. Micromachines (Basel). 2023 Dec 30; 15(1): 83. doi: 10.3390/mi15010083
Rachad Aita, Gopeekrishnan Unnithan, Radhakrishnan Unnithan, Tarek Klaylat, Joseph A Petruccelli, Guillaume St-Jean, Mohan Radhakrishna, Rahul Gawri, Chan Gao (2024). A novel mouse model of polytrauma with spinal cord injury–associated heterotopic ossification. European Cells and Materials. 47(0): 73-90, 2024: doi: 10.22203/eCM.v047a06
Ahmed Aoude, David Nikomarov, Jonathan R Perera, Izuchukwu K Ibe, Anthony M Griffin, Kim M Tsoi, Peter C Ferguson, Jay S Wunder (2023). Giant cell tumour of bone. The Bone & Joint Journal, 105-B(5), 559-567. doi:10.1302/0301-620X.105B5.BJJ-2022-1231.R1
Daniel G Bisson, Kai Sheng, Semsi Kocabas, Don Daniel Ocay, Catherine E Ferland, Neil Saran, Jean A Ouellet, Lisbet Haglund. Axial rotation and pain are associated with facet joint osteoarthritis in adolescent idiopathic scoliosis. Osteoarthritis Cartilage. 2023 Aug; 31(8): 1101-1110. doi: 10.1016/j.joca.2023.03.007
Leigh Gabel, Kyla Kent, Seyedmahdi Hosseinitabatabaei, Andrew Burghardt, M B Leonard, Frank Rauch, Bettina Willie (2023). Recommendations for High-resolution Peripheral Quantitative Computed Tomography Assessment of Bone Density, Microarchitecture, and Strength in Pediatric Populations. Curr Osteoporos Rep. 2023 Oct; 21(5): 609-623. doi: 10.1007/s11914-023-00811-9
Michael F Maalouf, Stephan Robitaille, Ruxandra Penta, Makena Pook, A Sender Liberman, Julio F Fiore Jr, Liane S Feldman, Lawrence Lee. Understanding the Impact of Bowel Dysfunction on Quality of Life After Rectal Cancer Surgery From the Patient's Perspective. Dis Colon Rectum. 2023 Aug 1; 66(8): 1067-1075. doi: 10.1097/DCR.0000000000002621
Emily Newell, Harriet Chorney, Christin A Tiegs-Heiden, John C Benson, Jean Ouellet, Mark Driscoll. Augmentation of musculoskeletal soft tissue morphology within low back pain patients may suggest the presence of physiological stress shielding: An in vivo study. J Biomech. 2024 Jan; 162: 111894. doi: 10.1016/j.jbiomech.2023.111894
Yassine Ouhaddi, Benjamin Dalisson, Arghavan Rastinfard, Mirko Gilardino, Kevin Watters, Dario Job, Parsa Azizi-Mehr, Geraldine Merle, Arturo Vela Lasagabaster, Jake Barralet. Necrosis reduction efficacy of subdermal biomaterial mediated oxygen delivery in ischemic skin flaps: Biomaterials Advances, Volume 153, 2023, 213519, ISSN 2772-9508, doi: 10.1016/j.bioadv.2023.213519
Marie-Eve Robinson, Damian Rauch, Francis H Glorieux, Frank Rauch. Standardized growth charts for children with osteogenesis imperfecta. Pediatr Res. 2023 Sep; 94(3): 1075-1082. doi: 10.1038/s41390-023-02550-0
Majid Roshanfar, Salar Taki, Amir Sayadi, Renzo Cecere, Javad Dargahi, Amir Hooshiar. Hyperelastic Modeling and Validation of Hybrid-Actuated Soft Robot with Pressure-Stiffening. Micromachines. 2023; 14(5):900. doi: 10.3390/mi14050900
Brittany Stott, Mark Driscoll. Development and evaluation of sex-specific thoracolumbar spine finite element models to study spine biomechanics. Med Biol Eng Comput. 2024 Apr;62(4):1191-1199. doi: 10.1007/s11517-023-03003-w
Joshua Vorstenbosch, Paola Ghione, George Plitas, Steven Horwitz, Minji Kim, Peter Cordeiro, Jonas Nelson, Colleen McCarthy. ASO Visual Abstract: Surgical Management and Long-Term Outcomes of BIA-ALCL: A Multidisciplinary Approach. Annals of surgical oncology. 31(3): 2042-2043, 2024: doi: 10.1245/s10434-023-14733-4
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TRANSLATIONAL RESEARCH IN RESPIRATORY DISEASES (RESP) PROGRAM
Nisha D Almeida, Ian Schiller, Danbing Ke, Elsa Sakr, Maria Plesa, Sandeep Vanamala, Anne-Laure Moneger, Maria Bazan, Chiara Lucchesi, Natalia Wozniak, Jorg H Fritz, Ciriaco A Piccirillo, Martin Pelchat, Corey Arnold, Yannick Galipeau, Pauline S McCluskie, Marc-Andre Langlois, Kaberi Dasgupta, Bruce D Mazer. The effect of dose-interval on antibody response to mRNA COVID-19 vaccines: a prospective cohort study: Frontiers in Immunology 15(0): 0, 2024: doi: 10.3389/fimmu.2024.1330549
Deborah Assayag, Ayodeji Adegunsoye, Robert Sheehy, Julie Morisset, Nasreen Khalil, Kerri A Johannson, Veronica Marcoux, Martin Kolb, Jolene H Fisher, Helene Manganas, Jeremy Wrobel, Margaret Wilsher, Sally De Boer, John Mackintosh, Daniel C Chambers, Ian Glaspole, Gregory J Keir, Cathryn T Lee, Renea Jablonski, Rekha Vij, Mary E Strek, Tamera J Corte, Christopher J Ryerson. Sex- and Race-Based Differences in the Treatment of Interstitial Lung Diseases in North America and Australasia: Chest 163(5): 1156-1165, 2023: doi: 10.1016/j.chest.2022.12.039
Yue Chen, Sarah MacIsaac, Matthew Young, Marlene Ahodakin, Luke Wan Jeagal, Maryse Boucher, Jason Agulnik, Nathalie Boulanger, Sophie Camilleri-Broët, Nicole Ezer, Anne V Gonzalez, Scott Owen, Carmela Pepe, Jonathan Spicer, Hangjun Wang, Shirley White-Dupuis, Larry Watt, Minnie Grey, Andrea Benedetti, Faiz Ahmad Khan. Nunavimmi puvakkut kaggutimik aanniaqarniq: Qanuilirqitaa? Lung cancer in Nunavik: How are we doing? A retrospective matched cohort study. CMAJ 2024 February 20; 196: E177-86. doi: 10.1503/cmaj.230682
Zahraa Haidar, Hussein Traboulsi, David H Eidelman, Carolyn J Baglole. Differential inflammatory profile in the lungs of mice exposed to cannabis smoke with varying THC:CBD ratio: Archives of Toxicology 97(7): 1963-1978, 2023: doi: 10.1007/s00204-023-03514-3
Nelly Huynh, Léa Drouin-Gagné, Camille Gilbert, Jean-Patrick Arcache, Pierre Rompré, Anne-Maude Morency, Robert Gagnon, John Kimoff, Sushmita Pamidi. Adherence and efficacy of mandibular advancement splint treatment of sleep-disordered breathing during pregnancy: a pilot study: Sleep and Breathing 27(3): 869-877, 2023: doi: 10.1007/s11325-022-02681-4
Aria Ed Jordan, Ntwali Placide Nsengiyumva, Rein M G J Houben, Peter J. Dodd, Katie D Dale, James M Trauer, Justin T Denholm, James C Johnston, Faiz Ahmad Khan, Jonathon R Campbell, Kevin Schwartzman. The prevalence of tuberculosis infection among foreign-born Canadians: a modelling study. CMAJ. 2023 Dec 10; 195(48): E1651-E1659. doi: 10.1503/cmaj.230228
Rami Karkout, Véronique Gaudreault, Lydia Labrie, Haya Aldossary, Noelia Azalde Garcia, Jichuan Shan, Elizabeth D Fixman. Female-specific enhancement of eosinophil recruitment and activation in a type 2 innate inflammation model in the lung: Clinical and Experimental Immunology 216(1): 13-24, 2024: doi: 10.1093/cei/uxad100
Jean-Philippe Leduc-Gaudet, Kayla Miguez, Marina Cefis, Julie Faitg, Alaa Moamer, Tomer Jordi Chaffer, Olivier Reynaud, Felipe E Broering, Anwar Shams, Dominique Mayaki, Laurent Huck, Marco Sandri, Gilles Gouspillou, Sabah N A Hussain. Autophagy ablation in skeletal muscles worsens sepsis-induced muscle wasting, impairs whole-body metabolism, and decreases survival: iScience 26(8):0, 2023: doi: 10.1016/j.isci.2023.107475
Bryan A Ross, Dany Doiron, Andrea Benedetti, Shawn D Aaron, Kenneth Chapman, Paul Hernandez, François Maltais, Darcy Marciniuk, Denis E O'Donnell, Don D Sin, Brandie L Walker, Wan Tan, Jean Bourbeau;. Short-term air pollution exposure and exacerbation events in mild to moderate COPD: A case-crossover study within the CanCOLD cohort: Thorax 78(10): 974-982, 2023: doi: 10.1136/thorax-2022-219619
Kim A Tran, Erwan Pernet, Mina Sadeghi, Jeffrey Downey, Julia Chronopoulos, Elizabeth Lapshina, Oscar Tsai, Eva Kaufmann, Jun Ding, Maziar Divangahi. BCG immunization induces CX3CR1hi effector memory T cells to provide cross-protection via IFN-γ-mediated trained immunity: Nature Immunology 25(3): 418-431, 2024: doi: 10.1038/s41590-023-01739-z
Motahareh Vameghestahbanati, Coralynn Sack, Artur Wysoczanski, Eric A Hoffman, Elsa Angelini, Norrina B Allen, Alain G Bertoni, Junfeng Guo, David R Jacobs Jr, Joel D. Kaufman, Andrew Laine, Ching-Long Lin, Daniel Malinsky, Erin D Michos, Elizabeth C Oelsner, Steven J Shea, Karol E Watson, Andrea Benedetti, R Graham Barr, Benjamin M Smith. Association of dysanapsis with mortality among older adults. Eur Respir J. 2023 Jun 8; 61(6): 2300551. doi: 10.1183/13993003.00551-2023
Muyang Zhou, Rui Sun, Rohin Chakraborty, Christina Wang, Anne-Marie Lauzon, James G. Martin. CD4+ T cell-derived IFN-γ and LIGHT synergistically upregulate chemokine production from airway smooth muscle cells: FASEB Journal 38(2): 0, 2024: doi: 10.1096/fj.202301428RR
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