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lipoproteins • high-density lipoprotein (HDL) • familial hypercholesterolemia • genetics • ABCA1
My research focuses on better understanding the genetic and metabolic factors in premature coronary artery disease in man. A major focus is the study of genetic factors that modulate plasma lipoproteins and apolipoprotein levels. I have undertaken four broad areas of research in the past 30 years. These include the genetics of low high-density lipoprotein (HDL) cholesterol states and biogenesis of HDL particles. In the latter area, my laboratory has studied the molecular cellular physiology of cholesterol transport. A third initiative was to set up a Cardiology/Prevention Clinic in which metabolic and genetic factors leading to coronary artery disease are studied. This clinic provides a service to patients with premature coronary artery disease. A fourth research initiative relates to the Canadian FH (Familial Hypercholesterolemia) Foundation.
Akioyamen LE, Genest J, Shan SD, Reel RL, Albaum JM, Chu A, Tu JV. Estimating the prevalence of heterozygous familial hypercholesterolaemia: a systematic review and meta-analysis. BMJ Open. 2017 Sep 1;7(9):e016461. PMID: 28864697.
Ridker PM, Everett BM, Thuren T, MacFayden JG, Chang WH, Ballantyne C, Fonseca F, Nicolau J, Koening W, Anker SD, Kastelein JJP, Cornel AH, Pais P, Pella D, Genest J, Cifkova R, Lorenzatti A, Forster T, Kobalava Z, Vida-Simiti L, Flather M, Shimokawa H, Ogawa H, Dellborg M, Rossi PRF, Troquay RPT, Libby P, Glynn RJ for the CANTOS Trial Group. Antiinflammatory therapy with Canakinumab for Atherosclerotic Disease. New England Journal of Medicine 2017 Sep 21;377(12):1119-1131. PMID: 28845751.
Choi H, Ruel I, Malina A, Garrod DR, Oda M, Pelletier J, Schwertain A, Genest J. Desmocollin 1 is abundantly expressed in atherosclerosis and impairs HDL biogenesis. Eur Heart J. 2018 Apr 7;39(14):1194-1202. [CIHR MOP 15042] [*].
Brunham LR, Ruel I, Aljenedil S, Rivière J-B, Baass A, Tu JV, Mancini JBJ, Raggi P,Gupta M, Couture P, Pearson HJ, Bergeron J, Francis GA, McCrindle BW, Morrison K, St-Pierre J, Henderson M, Hegele RA, Genest J. Canadian Cardiovascular Society Position Statement on Familial Hypercholesterolemia. [†] Can J Cardiol 2018;34(12):1553-1563.
Hafiane A, Johansson JO, Genest J. ABCA1 agonist mimetic peptide CS-6253 induces microparticles release from different cell types by ABCA1-efflux dependent mechanism. Can J Cardiol 2019;35:770-781 [*] CIHR MOP 15042.