David Goltzman, MD
parathyroid hormone • vitamin D • calcium • osteoporosis
My research focuses on the laboratory investigation of the hormonal regulation of mineral and skeletal metabolism and also on epidemiologic studies of osteoporosis, the most prevalent form of bone disease.My colleagues and I have examined the demographics, development, risk factors and outcomes of osteoporosis and of osteoporotic fractures. My approach therefore has been to evaluate bone disease in the population, but to anchor these observations with important insights from the laboratory.
Goltzman D, and Hendy G The calcium-sensing receptor in bone-mechanistic and therapeutic insights. Nature Reviews Endocrinology. 2015In press PMID: 25752283.
Langsetmo L, Berger C, Kreiger N, Kovacs C S, Hanley D A,. Jamal S A, Whiting S J, Genest J,Morin S N, Hodsman A, Prior J C, Lentle B, Patel M S, Brown JP, Anastasiades T, Towheed T, Josse R G, Papaioannou A, Adachi J D,. Leslie W D, Davison K. S, Goltzman D, and the CaMos Group. Calcium and Vitamin D Intake and Mortality: Results from the Canadian Multi-centre Osteoporosis Study J Clin Endocrinol Metab, 2013 Jul;98(7):3010-8.. PMID: 23703722.
Leong A, Rehman W, Dastani Z, Greenwood C, Timpson N, Langsetmo L, Berger C; METASTROKE, Fu L, Wong BY, Malik S, Malik R, Hanley DA, Cole DE, Goltzman D, Richards JB. The causal effect of vitamin D binding protein (DBP) levels on calcemic and cardiometabolic diseases: a Mendelian randomization study. PLoS Med. 2014 Oct 28;11(10):e1001751 PMID: 25350643.
Salehi-Tabar R, Nguyen-Yamamoto L, Tavera-Mendoza LE, Quail T, Dimitrov V, An BS, Glass L, Goltzman D, White JH.Vitamin D receptor as a master regulator of the c-MYC/MXD1 network Proc Natl Acad Sci U S A. 2012 Nov 13;109(46):18827-32.
Miao D, Su H, He B, Gao J, Xia Q, Zhu M, Gu Z, Goltzman D, Karaplis AC.Severe growth retardation and early lethality in mice lacking the nuclear localization sequence and C-terminus of PTH-related protein.Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20309-14 PMID: 19091948.