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RI-MUHC ANNUAL REPORT 2020

null YEAR IN REVIEW: Cancer Research Program (CRP)

RESEARCH HIGHLIGHTS

High-fat diet fuels prostate cancer progression by mimicking key cancer alteration

David Labbé, PhD
David Labbé, PhD

New study suggests that dietary intervention to reduce fat consumption could improve prostate cancer outcome.

David Labbé (PhD) is study co-lead (Nature Communications).

His team demonstrated that saturated fat intake induces a cellular reprogramming that drives prostate cancer progression and lethality.

Estrogen induces liver metastasis immune tolerance in females

Pnina Brodt, PhD (centre), and team
Pnina Brodt, PhD (centre), and team

Reported in Nature Communications by Pnina Brodt (PhD) and team, this study may explain why female sex and liver metastases predict a poorer response to immunotherapy.

Study provides a rationale to explore the potential of anti-estrogens as treatment for hormone-independent cancers that metastasize to the liver.

SELECTED PUBLICATIONS

Alexis Rompré-Brodeur, Surashri Shinde-Jadhav, Mina Ayoub, Ciriaco A. Piccirillo, Jan Seuntjens, Fadi Brimo, Jose Joao Mansure, Wassim Kassouf. PD-1/PD-L1 immune checkpoint inhibition with radiation in bladder cancer: In situ and abscopal effects. Molecular Cancer Therapeutics. 19(1): 211-220, 2020.

André Diamant, Veng Jean Heng, Avishek Chatterjee, Sergio Faria, Houda Bahig, Edith Filion, Robert Doucet, Farzin Khosrow-Khavar, Issam El Naqa, Jan Seuntjens. Comparing local control and distant metastasis in NSCLC patients between CyberKnife and conventional SBRT. Radiotherapy and Oncology 144(): 201-208, 2020.

Matthew Seidler, Behzad Forghani, Caroline Reinhold, Almudena Pérez-Lara, Griselda Romero-Sanchez, Nikesh Muthukrishnan, Julian L Wichmann, Gabriel Melki, Eugene Yu, Reza Forghani. Dual-Energy CT Texture Analysis with Machine Learning for the Evaluation and Characterization of Cervical Lymphadenopathy. Comput Struct Biotechnology Journal. 17:1009-1015, 2019.

Michelle Le, Feras M Ghazawi, Elham Rahme, Akram Alakel, Elena Netchiporouk, Evgeny Savin, Andrei Zubarev, Steven J Glassman, Denis Sasseville, Gizelle Popradi, Ivan V Litvinov. Identification of significant geographic clustering of polycythemia vera cases in Montreal, Canada. Cancer 125(22): 3953-3959, 2019.

Nisreen S. Ibrahim, Anthoula Lazaris, Miran Rada, Stephanie K. Petrillo, Laurent Huck, Sabah Hussain, Shaida Ouladan, Zu-Hua Gao, Alexander Gregorieff, Rachid Essalmani, Nabil G. Seidah, Peter Metrakos. Angiopoietin1 deficiency in hepatocytes affects the growth of colorectal cancer liver metastases (Crclm). Cancers 12(1), 2020.

Stephen Donald Gowing, Simon C. Chow, Jonathan J. Cools-Lartigue, Crystal B. Chen, Sara Najmeh, Marnie Goodwin-Wilson, Henry Y. Jiang, France Bourdeau, Annie Beauchamp, Isabelle Angers, Betty Giannias, Jonathan D. Spicer, Simon Rousseau, Salman T. Qureshi, Lorenzo Edwin Ferri. Gram-Negative Pneumonia Augments Non–Small Cell Lung Cancer Metastasis through Host Toll-like Receptor 4 Activation. Journal of Thoracic Oncology 14(12):2097-2108, 2019.

Stéphane Renaud, Joseph Seitlinger, Yaseen Al Lawati, Francesco Guerrera, Pierre Emmanuel Falcoz, Gilbert Massard, Lorenzo Edwin Ferri, Jonathan D. Spicer. Anatomical resections improve survival following lung metastasectomy of colorectal cancer harboring KRAS. Annals of Surgery 270(6):1170-1177, 2019.

Zeinab Sharifi, Bassam Samuel Abdulkarim, Brian Meehan, Janusz W. Rak, Paul Daniel, Julie Schmitt, Nidia Lauzon, Kolja Eppert, Heather M. Duncan, Kevin Petrecca, Marie Christine Guiot, Bertrand Jean-Claude, Siham Sabri. Mechanisms and antitumor activity of a binary EGFR/DNA–targeting strategy overcomes resistance of glioblastoma stem cells to temozolomide. Clinical Cancer Research 25(24):7594-7608, 2019.

Cancer Research Program (CRP)

rimuhc.ca/CRP