YEAR IN REVIEW: Metabolic Disorders and Complications Program (MeDiC) - Research Institute of the McGill University Health Centre

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null YEAR IN REVIEW: Metabolic Disorders and Complications Program (MeDiC)

RESEARCH HIGHLIGHTS

New criteria for diagnosing sarcopenia

Stéphanie Chevalier (RD, PhD) and doctoral student Anne-Julie Tessier, with Dr. Simon Wing, Elham Rahme (PhD) and Dr. José Morais, developed a tool that provides health professionals with a standard to diagnose sarcopenia and implement prevention strategies to delay its effects.

Stéphanie Chevalier, RD, PhD, and Anne-Julie Tessier — **Stéphanie Chevalier, RD, PhD,** and Anne-Julie Tessier

Mitigation of the risk of kidney transplant loss

Dr. Ruth Sapir-Pichhadze and colleagues including Dr. Bethany Foster, Child Health and Human Development Program, demonstrated that donorrecipient matching for specific features of HLA genes would be a useful strategy to decrease kidney transplant failures.

Overcoming resistance in malignant brain tumours

Bertrand Jean-Claude (PhD) and colleagues, including study lead Siham Sabri (PhD) of the Cancer Research Program, demonstrated the anti-tumour activity of a combi-molecule to overcome resistance of glioblastoma stem cells to DNA-damaging chemotherapy.

SELECTED PUBLICATIONS

Ahmad Haidar, Michael A. Tsoukas, Sarah Bernier-Twardy, Jean François Yale, Joanna Rutkowski, Anne Bossy, Evelyne Pytka, Anas El-Fathi, Natalia Strauss, Laurent Legault. A novel dual-hormone insulin- and-pramlintide artificial pancreas for type 1 diabetes: A randomized controlled crossover trial. Diabetes Care 43(3):597-606, 2020.

Angel M. Ong, Kai Kang, Hope Alberta Weiler, Suzanne N. Morin. Fermented Milk Products and Bone Health in Postmenopausal Women: A Systematic Review of Randomized Controlled Trials, Prospective Cohorts, and Case-Control Studies. Advances in Nutrition 11(2):251-265, 2020.

Emily Machiela, Thomas Liontis, Dylan J. Dues, Paige D. Rudich, Annika Traa, Leslie Wyman, Corah Kaufman, Jason F. Cooper, Leira Lew, Saravanapriah Nadarajan, Megan M. Senchuk, Jeremy M. Van Raamsdonk. Disruption of mitochondrial dynamics increases stress resistance through activation of multiple stress response Pathways. FASEB Journal 34(6):8475-8492, 2020.

Jill Pancer, Nancy Wu, Ibtisam Mahmoud, Kaberi Dasgupta. Pharmacological intervention for diabetes after pregnancy prevention in women with prior gestational diabetes: A scoping review. Diabetes Research and Clinical Practice 160:107998, 2020.

Jun Matsuda, Mirela Maier, Lamine Aoudjit, Cindy Baldwin, Tomoko Takano. ARHGEF7 (ß-PIX) Is Required for the Maintenance of Podocyte Architecture and Glomerular Function. Journal of the American Society of Nephrology: JASN 31(5):996-1008, 2020.

Laurence Gagnon, Yubo Cao, Aaron Cho, Dana Sedki, Thomas L. Huber, Thomas P. Sakmar, Stéphane A. Laporte. Genetic code expansion and photocross-linking identify different ß-arrestin binding modes to the angiotensin II type 1 receptor. Journal of Biological Chemistry 294(46): 17409-17420, 2019.

Loan Nguyen-Yamamoto, Kenichiro Tanaka, Rene St- Arnaud, David Goltzman. Vitamin D–regulated osteocytic sclerostin and BMP2 modulate uremic extraskeletal calcification. JCI Insight 4(13):e126467, 2019.

Marie Ève Robinson, Marc Simard, Isabelle Larocque, Jai Shah, Meranda M. Nakhla, Elham Rahme. Risk of psychiatric disorders and suicide attempts in emerging adults with diabetes. Diabetes Care 43(2):484-486, 2020.