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immunology • T cell biology • autoimmune diseases • inflammatory diseases
My research focuses on the regulation of innate and adaptive immune responses mediated by Foxp3+ regulatory T (Treg) cells, a unique population of CD4+ T cells with potent immunosuppressive functions in humans and mice. Normal development and function of Foxp3+ Treg cells is essential for the protection from autoimmune diseases and developmental or functional defects in Treg cells in mice and humans unequivocally provokes many inflammatory and autoimmune diseases. Our research is responsible for many seminal studies over the past decade related to the function and mechanism of action of Treg cells in a variety of animal models, non-human primates and humans. My research program aims to determine whether Treg cell developmental, functional or homeostatic deficiencies trigger various inflammatory disorders, and in particular autoimmune diseases like type 1 diabetes (T1D). My laboratory exploits a spectrum of molecular and cellular approaches to study the development, dynamics and molecular basis of Treg cell function in health and disease.
Bin Dhuban K et al. Coexpression of TIGIT and FCRL3 identifies Helios+ human memory regulatory T cells. J Immunol. 2015 Apr 15;194(8):3687-96. PMID: 25762785.
Piccirillo CA et al. Translational control of immune responses: from transcripts to translatomes. Nat Immunol. 2014 Jun;15(6):503-11. PMID: 24840981.
Bjur E et al. Distinct translational control in CD4+ T cell subsets. PLoS Genet. 2013 May;9(5):e1003494. PMID: 23658533.
Kornete M et al. ICOS-dependent homeostasis and function of Foxp3+ regulatory T cells in islets of nonobese diabetic mice. J Immunol. 2012 Feb 1;188(3):1064-74. PMID: 22227569.
d'Hennezel E et al. FOXP3 forkhead domain mutation and regulatory T cells in the IPEX syndrome. N Engl J Med. 2009 Oct 22;361(17):1710-3. PMID: 19846862.