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Where: At the Research Institute of the McGill University Health Centre (RI‑MUHC) Glen Site, block E, room M1.3509, 1001 Decarie Boulevard, Montreal, Quebec H4A 3J1
When: Wednesday, October 30, 12 p.m.
Speaker: Jean-Pierre Routy, MD, FRCPC
Clinical Director of the Chronic Viral Illness Service
Division of Hematology and Chronic Viral Illness Service
Louis Lowenstein Chair in Hematology & Oncology
Professor of Medicine, McGill University
Endotoxemia, inflammation and HIV: Revisiting an old concept
Endotoxemia is the change in the permeability of the intestinal flora, which allows the passage of lipopolysaccharide derived from intestinal bacteria into the bloodstream. Outside sepsis, low level of endotoxemia occurs during IBDs, obesity and metabolic syndrome contributing to inflammatory morbidity that include cardio-vascular disease, liver steatosis and cancer. Recently, HIV infection has been also associated with endotoxemia that persists on ART. In addition to LPS, we have showed that both latent CMV co-infection and fungal translocation also contribute to increase gut permeability and endotoxemia. New therapeutic strategies are needed to reduce endotoxemia to limit non-AIDS morbidity and to improve vaccine response.
Click here to view the poster for this event.