Breadcrumb

null Per Jesper Sjöström, M.Sc., PhD

Scientist, RI-MUHC, Montreal General Hospital site

Brain Repair and Integrative Neuroscience (BRaIN) Program

Centre for Translational Biology

Professor, Department of Neurology and Neurosurgery, Faculty of Medicine and Health Sciences, McGill University

 

Keywords

synaptic plasticity • learning and memory • neuronal circuits • synaptic disease

Research Focus

My research focuses on understanding the functioning of the brain, by elucidating the properties and the mechanistic underpinnings of plasticity, as well as its functional impact. In addition, we investigate the connectivity patterns that ensue from plasticity and how these are shaped by activity. Our goal is to understand the role of plasticity in health as well as in pathologies such as epilepsy and autism. To do this, my team employs state-of-the-art technology such as quadruple whole-cell recordings, two-photon laser scanning microscopy, and computer simulations.

Selected Publications

Click on Pubmed to see my current publications list

  • Watanabe A, Guo C, Sjöström PJ: The Developmental Profile of Visual Cortex Astrocytes.iScience (2023) doi: 10.1016/j.isci.2023.106828. PMID: 37250801.

  • McFarlan AR, Chou CYC, Watanabe A, Cherepacha N, Haddad M, Owens H, & Sjöström PJ: The plasticitome of cortical interneurons. Nature Reviews Neuroscience (2023) doi: 10.1038/s41583-022-00663-9. PMID: 36585520.

  • Chou CYC, Wong HHW, Guo C, Boukoulou KE, Huang C, Jannat J, Klimenko T, Li VY, Liang TA, Wu VC, Sjöström PJ. Principles of visual cortex excitatory microcircuit organization. Innovation (Camb). 2024 Dec 12;6(1):100735. doi: 10.1016/j.xinn.2024.100735. eCollection 2025 Jan 6. PMID: 39872485.

  • Cela E, McFarlan AR, Chung AJ, Wang T, Chierzi S, Murai KK, & Sjöström PJ: An Optogenetic Kindling Model of Neocortical Epilepsy. Scientific Reports (2019) 9:5236. DOI: 10.1038/s41598-019-41533-2. PMID: 30918286.

  • Wong HH, Watt AJ, Sjöström PJ. Synapse-specific burst coding sustained by local axonal translation. Neuron. 2024 Jan 17;112(2):264-276.e6. doi: 10.1016/j.neuron.2023.10.011. Epub 2023 Nov 8. PMID: 37944518.