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null Sabah Hussain, MD, PhD

Senior Scientist, RI-MUHC, Glen site

Translational Research in Respiratory Diseases Program

Centre for Translational Biology

Professor, Department of Medicine, Faculty of Medicine and Health Sciences, McGill University

 

Keywords

endothelial cells • angiogenesis • skeletal muscle atrophy

Research Focus

My research focuses on molecular mechanisms that regulate skeletal muscle function and mass in health and disease. Loss of muscle mass (atrophy) develops in several respiratory pathologies, such as chronic obstructive pulmonary disease, and in patients with critical illnesses. In these conditions, muscle atrophy is a major determinant of the quality of life and survival. My laboratory focuses on identifying novel genes that promote or prevent muscle atrophy in general and genes that determine or regulate muscle protein degradation pathways such as autophagy and proteasome pathways. My laboratory also investigates epigenetic mechanisms involved in the regulation of skeletal muscle atrophy, including micro RNAs and long non-coding RNAs.

Selected Publications

Click on Pubmed to see my current publications list

  • Parkin Overexpression Attenuates Sepsis-Induced Muscle Wasting. Jean-Philippe Leduc-Gaudet, Dominique Mayaki, Olivier Reynaud , Felipe E Broering, Tomer J Chaffer , Sabah N A Hussain , Gilles Gouspillou. Cells 2020 Jun 11;9(6):1454.

  • Contribution of the Mitochondria to Locomotor Muscle Dysfunction in Patients With COPD. Tanja Taivassalo and Sabah NA Hussain. Chest 149(5):1302-12, 2016.

  • Differential Regulation of the Autophagy and Proteasome Pathways in Skeletal Muscles in Sepsis. Flavia Stana, Marija Vujovic, Dominique Mayaki, Jean-Philippe Leduc-Gaudet, Philippe Leblanc, Laurent Huck, Sabah N A Hussain. Critical Care Medicine 2017 Sep;45(9):e971-e979.

  • Long Non-coding RNA Rhabdomyosarcoma 2-Associated Transcript Regulates Angiogenesis in Endothelial Cells. Maha Alaqeeli, Dominique Mayaki , Sabah N A Hussain . Frontiers of Physiology 2021 Oct 21;12:729157.

  • Parkin overexpression protects from ageing-related loss of muscle mass and strength. Jean-Philippe Leduc-Gaudet, Olivier Reynaud, Sabah N Hussain, Gilles Gouspillou. Journal of Physiology 2019 Apr;597(7):1975-1991.