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RI-MUHC ANNUAL REPORT 2023
YEAR IN REVIEW
CHILD HEALTH AND HUMAN DEVELOPMENT (CHHD) PROGRAM
RESEARCH HIGHLIGHTS
CHILD-BRIGHT Network moving forward with $9M in funding
Headed by Child Health and Human Development (CHHD) Program researcher Annette Majnemer, the CHILD-BRIGHT Network creates an inclusive community for equity-driven knowledge mobilization and implementation science. In the past year, this national network earned a Strategy for Patient-Oriented Research (SPOR) Networks Knowledge Mobilization and Implementation Science Grant from the CIHR to initiate CHILD-BRIGHT Phase 2. A special focus is on moving patient-oriented research into action through insight and methods grounded in implementation science and knowledge mobilization, while integrating the principles of equity, diversity, inclusion, decolonization and Indigenization.
Liquid biopsy: The next frontier in pediatric cancer screening, diagnosis and treatment
CHHD Program researcher Janusz Rak and collaborators Nada Jabado (CHHD Program), Claudia Kleinman (McGill University and the Lady Davis Institute for Medical Research), Livia Garzia and Joanna Przybyl (Cancer Research Program, RI-MUHC), and Sarah Mahshid (McGill University), received a 6M$ donation to develop a simple blood or urine test ─ a liquid biopsy ─ that will replace risky surgical biopsies to determine if a suspicious lump is cancerous and pinpoint the exact type of cancer. Read more in the central feature of this report.
Deciphering the complex biology of pediatric cancers
A Montreal research team has demonstrated how genetic mutations cause brain cell death and inflammation by derailing synaptic pruning. By examining the developmental consequences of three specific histone mutations (H3.3G34R, V and W), the team, led by researchers Nada Jabado and Livia Garzia at the RI-MUHC, together with Claudia Kleinman at the Lady Davis Institute for Medical Research, unravelled a genetic mechanism that leads to severe neurodevelopmental syndromes. Read more in the central feature of this report. (Cell, doi: 10.1016/j.cell.2023.02.023)
Selected CHHD Program news links
- Liquid biopsy research: a generous boost to help children with cancer
- Too much pruning: A new study sheds light on how neurodegeneration occurs in the brain
- Researchers discover how brain cells may be hardwired for vulnerability to deadly childhood brain tumour
- Announcing CHILD-BRIGHT Phase 2! (CHILD-BRIGHT Network website)
- Giving children with brain-based developmental disabilities a voice in research
- Big start for the Canadian Mother-Child Collaborative Training Platform – CAMCCO-L
- Endometriosis seems to increase the risk of preeclampsia
- Canada’s Most Powerful Women: Top 100 Award goes to former doctoral student at the RI-MUHC
- MORE CHHD news
SELECTED PUBLICATIONS
Lata H. Adnani, Jordan Kassouf, Brian Meehan, Cristiana Spinelli, Nadim Tawil, Ichiro Nakano, Janusz W. Rak. Angiocrine extracellular vesicles impose mesenchymal reprogramming upon proneural glioma stem cells: Nature Communications 13(1):0, 2022: doi: 10.1038/s41467-022-33235-7
Esli Osmanlliu, Isabelle Gagnon, Saskia Weber, Chi Quan Bach, Jennifer Turnbull, Jade Séguin. The Waiting Room Assessment to Virtual Emergency Department pathway: Initiating video-based telemedicine in the pediatric emergency department: Journal of Telemedicine and Telecare 28(6): 452-457, 2022: doi: 10.1177/1357633X211044038
Nam Tien Tran Nguyen, Etienne Léveillé, Elena Guadagno, Luc Malemo Kalisya, Dan Poenaru. Use of mobile health technologies for postoperative care in paediatric surgery: A systematic review: Journal of Telemedicine and Telecare 28(5): 331-341, 2022: doi: 10.1177/1357633X20934682
Jennifer M. Ladd, Atul Kumar Sharma, Elham Rahme, Kristine Kroeker, Marjolaine Dubé, Marc Simard, Céline Plante, Claudia Blais, Marni Brownell, Celia J. Rodd, Meranda M. Nakhla. Comparison of Socioeconomic Disparities in Pump Uptake among Children with Type 1 Diabetes in 2 Canadian Provinces with Different Payment Models: JAMA Network Open 5(5):0, 2022: doi: 10.1001/jamanetworkopen.2022.10464
Donovan Chan, Kathleen Oros-Klein, Antoni Riera-Escamilla, Csilla Krausz, C. O'Flaherty, Peter T.k. Chan, Bernard Robaire, Jacquetta M. Trasler. Sperm DNA methylome abnormalities occur both pre- and post-treatment in men with Hodgkin disease and testicular cancer: Clinical Epigenetics 15(1):0, 2023: doi: 10.1186/s13148-022-01417-1
Menal Huroy, Tarannum Behlim, John C. Andersen, David J. Buckley, Darcy L. Fehlings, Adam Kirton, Nicole Pigeon, Ram A. Mishaal, Ellen P. Wood, Michael Israel Shevell, Maryam Oskoui. Stability of the Gross Motor Function Classification System over time in children with cerebral palsy: Developmental Medicine and Child Neurology 64(12): 1487-1493, 2022: doi: 10.1111/dmcn.15375
Kaitlyn Easson, Guillaume Gilbert, Charles V. Rohlicek, Christine Saint-Martin, Maxime Descoteaux, Sean C.L. Deoni, Marie Brossard-Racine. Altered myelination in youth born with congenital heart disease: Human Brain Mapping 43(11): 3545-3558, 2022: doi: 10.1002/hbm.25866
Valérie Courchesne, Rackeb Tesfaye, Pat L. Mirenda, David Bruce Nicholas, Wendy Mitchell, Ilina Singh, Lonnie Zwaigenbaum, M. Elsabbagh. Autism Voices: A novel method to access first-person perspective of autistic youth: Autism 26(5): 1123-1136, 2022: doi: 10.1177/13623613211042128
Marie Claude Beauchamp, Alexia Boucher, Yanchen Dong, Rachel Aber, Loydie Anne Jerome-Majewska. Craniofacial Defects in Embryos with Homozygous Deletion of Eftud2 in Their Neural Crest Cells Are Not Rescued by Trp53 Deletion: International Journal of Molecular Sciences 23(16):0, 2022: doi: 10.3390/ijms23169033
Seline Y. Vancolen, Taghreed A. Ayash, Mariela A. Segura, Marie Julie Allard, Bernard Robaire, Guillaume Sébire. Androgens Upregulate Pathogen‐Induced Placental Innate Immune Response: International Journal of Molecular Sciences 23(9):0, 2022: doi: 10.3390/ijms23094978
Don Daniel Ocay, Elizabeth F. Teel, Owen Dan Luo, Chloé Savignac, Yacine Mahdid, Stefanie Blain-Moraes, Catherine Estelle Ferland. Electroencephalographic characteristics of children and adolescents with chronic musculoskeletal pain: Pain Reports 7(6):0, 2022: doi: 10.1097/PR9.0000000000001054
Gabriella Le Blanc, Elias Jabbour, Sharina Patel, Olga Kazantseva, Marco Zeid, François Olivier, Wissam Shalish, Marc Beltempo. Organizational Risk Factors and Clinical Impacts of Unplanned Extubation in the Neonatal Intensive Care Unit: Journal of Pediatrics 249(0): 14-21.e5, 2022: doi: 10.1016/j.jpeds.2022.06.012
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