THE INSTITUTE ANNUAL REPORT 2025
BRAIN REPAIR AND INTEGRATIVE NEUROSCIENCE (BRaIN) PROGRAM
SELECTED HIGHLIGHTS
Optomapping: A breakthrough method for exploring synaptic connections in the brain
Pioneering technique developed by researchers at The Institute offers new insights into how neurons communicate
Scientists at The Institute have implemented a groundbreaking method called “optomapping,” which dramatically accelerates the study of neurons in the brain. Led by Jesper Sjöström, PhD, and published in The Innovation, this new work provides unprecedented insights into how neurons connect and communicate, offering hope for better understanding neurological disorders such as epilepsy and autism. Learn more
$10.6M grant supports innovative autism project
McGill Translational Platform in Autism Research will help uncover the disorder's neural foundations
A new project at The Neuro, McGill University and The Institute has been awarded $10.6M in financial support as part of the Canada Foundation for Innovation’s (CFI) Innovation Fund. The McGill Translational Platform in Autism Research (MTPAR) will harness cutting-edge technologies to uncover the neurobiological mechanisms behind autism spectrum disorders (ASDs), which affect social interaction and patterns of behaviour and interests in about one in 66 Canadians and one-to-two per cent of children globally. Learn more
More research highlights from the BRaIN Program
SELECTED PUBLICATIONS
Ronald B. Postuma, Nisa Vorasoot, Erik K.S.T. St Louis, Amélie Pelletier, Miranda M. Lim, Jonathan E. Elliott, Jean François Gagnon, Ziv Gan-Or, Leah K. Forsberg, Julie A. Fields, Owen A. Ross, Wolfgang Singer, Daniel E. Huddleston, Donald L. Bliwise, Alon Y. Avidan, Michael Joseph Howell, Carlos Hugh Schenck, Jennifer S. McLeland, Albert A. Davis, Susan R. Criswell, Aleksandar Videnović, Emmanuel H. During, Mitchell G. Miglis, Bradley Bradley Boeve, Yo El S. Ju, Andrew B. McKeon. IGLON5 Frequency in Idiopathic REM Sleep Behavior Disorder: A Multicenter Study. Neurology: Neuroimmunology and NeuroInflammation 11(6), 2024. DOI: 10.1212/NXI.0000000000200311
P. Tristin Best, John Cornelis van Swieten, Lize Corrine Jiskoot, Fermín Moreno, Raquel Sánchez-Valle Díaz, Robert Jr Laforce, Caroline Graff, Mario Masellis, Carmela Carmela Tartaglia, James Benedict Rowe, Barbara Borroni, Elizabeth C. Finger, Matthis Sy. Association of Changes in Cerebral and Hypothalamic Structure With Sleep Dysfunction in Patients With Genetic Frontotemporal Dementia. Neurology 103(11), 2024: 85209482460: DOI: 10.1212/WNL.0000000000209829
Christina You Chien Chou, Hovy Ho Wai Wong, Connie Guo, Kiminou E. Boukoulou, Cleo Huang, Javid Jannat, Tal Klimenko, Vivian Y. Li, Tasha A. Liang, Vivian C. Wu, Per Jesper Sjöström. Principles of visual cortex excitatory microcircuit organization. Innovation 6(1), 2025: 85213842468: DOI: 10.1016/j.xinn.2024.100735
Stefano Comai, Nicolás A. Nunez, Tobias Atkin, Maykel Farag Ghabrash, Rita Zakarian, Allan Fielding, Marie Saint-Laurent, Nancy Chooi Ping Low, Garrett J. Sauber, Eugenio Ragazzi, Cecilia J. Hillard, Gabriella Gobbi. Dysfunction in endocannabinoids, palmitoylethanolamide, and degradation of tryptophan into kynurenine in individuals with depressive symptoms. BMC Medicine 22(1), 2024. DOI: 10.1186/s12916-024-03248-8
Clifton O. Bingham, Susan J. Bartlett. Using patient reported outcomes measurement information system (PROMIS®) measures in rheumatoid arthritis clinical care, research, and trials. Seminars in Arthritis and Rheumatism 70, 2025. DOI: 10.1016/j.semarthrit.2024.152576
Jonathan Gallego-Rudolf, Alex I. Wiesman, Alexa Pichet-Binette, Sylvia Villeneuve, Sylvain Baillet. Synergistic association of Aβ and tau pathology with cortical neurophysiology and cognitive decline in asymptomatic older adults. Nature Neuroscience 27(11): 213-2137, 2024: 85204422807: DOI: 10.1038/s41593-024-01763-8
Claire Godard-Sebillotte, Sanjna Navani, Louis Rochette, Victoria Kubuta Massamba, Éric Pelletier, Edeltraut Kröger, Isabelle Vedel. Dementia Incidence in Quebec Over 20 Years. JAMA Network Open 7(12), 2024: 85211410945: DOI: 10.1001/jamanetworkopen.2024.47346
Andrea I. Luppi, S. Parker Singleton, Justine Y. Hansen, Keith Wakefield Jamison, Danilo Bzdok, Amy F. Kuceyeski, Richard F. Betzel, Bratislav Mišić. Contributions of network structure, chemoarchitecture and diagnostic categories to transitions between cognitive topographies. Nature Biomedical Engineering 8(9): 1142-1161, 2024: 85200603083: DOI: 10.1038/s41551-024-01242-2
Casey Paquola, Margaret Garber, Stefan Frässle, Jessica Royer, Yigu Zhou, Shahin Tavakol, Raúl Rodríguez-Cruces, Donna Gift Cabalo, Sofie Louise Valk, Simon B. Eickhoff, Daniel S. Margulies, Alan C. Evans, Katrin Amunts, Elizabeth A. Jefferies, Jonathan M. Smallwood, Boris C. Bernhardt. The architecture of the human default mode network explored through cytoarchitecture, wiring and signal flow. Nature Neuroscience 28(3): 654-664, 2025. DOI: 10.1038/s41593-024-01868-0
Charlotte Maschke, Jordan O'Byrne, Michele Angelo Colombo, Mélanie M. Boly, Olivia Gosseries, Steven T. Laureys, Mario Rosanova, Karim Jerbi, Stefanie Blain-Moraes. Critical dynamics in spontaneous EEG predict anesthetic-induced loss of consciousness and perturbational complexity. Communications Biology 7(1), 2024. DOI: 10.1038/s42003-024-06613-8
Fari Ryan, Christian Blex, The Dung Ngo, Marcel A. Kopp, Bernhard Michalke, Vivek Venkataramani, Laura Curran, Jan Markus Schwab, Klemens Ruprecht, Carolin Otto, Priya Jhelum, Antje Kroner, Samuel David. Ferroptosis inhibitor improves outcome after early and delayed treatment in mild spinal cord injury. Acta Neuropathologica 147(1), 2024. DOI: 10.1007/s00401-024-02758-2
Riya Elizabeth Thomas, Franziska Mudlaff, Kyra Schweers, William Todd Farmer, Aparna Suvrathan. Heterogeneity in Slow Synaptic Transmission Diversifies Purkinje Cell Timing. Journal of Neuroscience 44(37), 2024: 85204141913: DOI: 10.1523/JNEUROSCI.0455-24.2024
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