Breadcrumb

null Carolyn Jack, MD, PhD

Scientist, RI-MUHC , Glen site

Infectious Diseases and Immunity in Global Health Program

Centre for Translational Biology

Assistant Professor, Department of Medicine, Faculty of Medicine and Health Sciences, McGill University

Department of Medicine, Division of Dermatology, MUHC

 

Keywords

atopic dermatitis • NOD ligand • resident memory T cells • Staphylococcusaureus • T cells

Research Focus

I am a dermatologist and PhD-trained immunologist with expertise in molecular biology, cellular immunology, immunophenotyping of primary human cells and tissues, in vitro human pre-clinical modeling of disease, and skin biospecimen-enabled clinical trials. My clinical work and research are focused on adult atopic dermatitis (AD), the most common and most burdensome skin disorder worldwide, affecting 5-10% of adults in developed countries. My research goal is to identify disease-modifying interventions in chronic AD.

I have established the first Canadian disease-specific human skin and blood immunophenotyping lab, with a research program and immunophenotyping platform for investigating in situ and ex vivo mechanisms of chronic inflammation with adult AD patient skin, swabs, and blood. Patients are recruited from my specialized clinic, the Centre of Excellence for Atopic Dermatitis at the McGill University Health Centre, which is the first tertiary care centre in Canada dedicated to adult AD.

Selected Publications

Click on Pubmed to see my current publications list

  • Papp, K. A., Hong, C-H, Lansang, M. P., Turchin, I., Adam, D. N., Beecker, J. R., Bissonnette, R., Gooderham, M. J., Jack, C., Joseph, M., Lynde, C. W., Shear, N. H. 2021. Practical Management of Patients with Atopic Dermatitis on Dupilumab. Dermatology & Therapy. https://doi.org/10.1007/s13555-021-00586-w.

  • He, H., Bissonnette, R., Wu, J., Diaz, A., Saint-Cyr Proulx, E., Maari, C., Jack, C., Louis, M., Estrada, Y., Kruger, J.G., Zhang, N., Pavel, A.B., Guttman-Yassky, E. 2021. Tape strips detect distinct immune and barrier profiles in atopic dermatitis and psoriasis. The Journal of Allergy and Clinical Immunology. 2021 Jan;147(1):199-212. doi: 10.1016/j.jaci.2020.05.048. Epub 2020 Jul 21. PMID: 32709423.

  • Belmesk, L., Muntyanu, A., Cantin, E., AlHalees, Z., Jack, C., Le, M., Sasseville, D., Iannattone, L., Ben-Shoshan, M., Litvinov, I.V., Netchiporouk, E. 2021. Prominent Role of Type 2 Immunity in Skin Diseases-Beyond Atopic Dermatitis. J Cutan Med Surg. doi:10.1177/12034754211027858.

  • Maintz, L., Bieber, T., Bissonnette, R., Jack, C*. 2021. Measuring Atopic Dermatitis Disease Severity: The Potential for Electronic Tools to Benefit Clinical Care. The Journal of Allergy and Clinical Immunology: In Practice. Volume 9, Issue 4, 2021, Pages 1473-1486.e2, ISSN 2213-2198, https://doi.org/10.1016/j.jaip.2021.02.027.

  • Ratnarajah, K., Le, M., Muntyanu, A., Mathieu, S., Nigen, S., Litvinov, I. V., Jack, C., Netchiporouk, E. Inhibition of IL-13: A New Pathway for Atopic Dermatitis. 2020. J Cutan Med Surg. 2021 May-Jun;25(3):315-328. doi: 10.1177/1203475420982553. Epub 2020 Dec 22. PMID: 33350863.