Christian Rocheleau, PhD
epidermal growth factor receptor (EGFR) • Ras protein • Caenorhabditis elegans • Rab proteins • vesicular trafficking
My research focuses on understanding the mechanisms that regulate two fundamental cellular processes, cell signaling and protein trafficking, and interactions between these processes using genetic, cell biological and biochemical approaches. I use the nematode Caenorhabditis elegans as a model system. This simple worm allows us to study gene function, not only at the cellular level, but also in the context of animal development and physiology. The high conservation of genes between C. elegans and H. sapiens means that findings made in the worm will be relevant to human health.
Skorobogata, O., Escobar-Restrepo,J.M. and Rocheleau, C.E. (2014). An AGEF-1/Arf GTPase/AP-1 ensemble antagonizes LET-23 EGFR basolateral localization and signaling during C. elegans vulva induction. PLoS Genetics, 10, e1004728. PMID: 25329472.
Skorobogata, O. and Rocheleau, C.E. (2012). RAB-7 antagonizes LET-23 EGFR signaling during vulva development in Caenorhabditis elegans. PLoS ONE, 7, e36489. PMID: 22558469.
Sun, L., Liu, O., Desai, J., Karbassi, F., Sylvain, M.A., Shi, A., Zhou, Z., Rocheleau, C.E. and Grant, B.D. (2012). CED-10/Rac1 regulates endocytic recycling through the RAB-5 GAP TBC-2. PLoS Genetics, 8, e1002785. PMID: 22807685.
Chotard, L., Mishra, A.K., Sylvain, M.A., Tuck, S., Lambright, D.G. and Rocheleau, C.E. (2010). TBC-2 regulates RAB-5/RAB-7-mediated endosomal trafficking in C. elegans. Mol. Biol. Cell, 21, 2285-2296. PMID: 20462958.
Chotard, L., Skorobogata, O., Sylvain, M.A., Shrivastava, S. and Rocheleau, C.E. (2010). TBC-2 is required for embryonic yolk protein storage and larval survival during L1 diapause in Caenorhabditis elegans. PLoS ONE, 5, e15662. PMID: 21203392.