José Morais, MD - José Morais, MD - Research Institute MUHC
protein • muscle • muscle protein
My research focuses on the assessment of whole-body and muscle protein metabolism and protein requirements with age and in states of insulin resistance, including diabetes in older adults, using stable isotope methods. Recently, we are assessing the cellular regulatory mechanisms overseeing muscle protein synthesis and breakdown. Several studies involve the nutritional assessment of healthy and frail elderly persons with the aim of improving their nutritional status and level of physical function.
Chevalier S, Goulet E, Wykes L, Burgos SA and Morais JA. Protein anabolic responses to a fed steady state in healthy aging. J Gerontol A Biol Sci Med Sci 2011;66:681-8. PMID: 21436253.
Rahi B, Morais JA, Dionne IJ, Gaudreau P, Payette H, Shatenstein B. The combined effects of diet quality and physical activity on maintenance of muscle strength among diabetic older adults from the NuAge cohort. Experimental Gerontology 2014;49:40-46. PMID: 24269377.
Gouspillou G, Sgarioto N, Kapchinsky S, Purves-Smith F, Norris B, Pion CH, Barbat-Artigas S, Lemieux F, Taivassalo T, Morais JA, Aubertin-Leheudre M, Hepple RT. Increased sensitivity to mitochondrial permeability transition and myonuclear translocation of endonuclease G in atrophied muscle of physically active older humans.FASEB J. 2014;28(4):1621-33. PMID: 24371120.
Murphy J, Chevalier S, Gougeon R, Goulet ÉD, Morais JA. Effect of obesity and type 2 diabetes on protein anabolic response to insulin in elderly women. Exp Gerontol. 2015 Jun 8;69:20-26. doi: 10.1016/j.exger.2015.06.008. [Epub ahead of print] PMID: 26068615.
Matta J, Mayo N, Dionne IJ, Gaudreau P, Fulop T, Tessier D, Gray-Donald K, Shatenstein B, Morais JA. Muscle mass index and animal source of dietary protein are positively associated with insulin resistance in participants of the NuAge study. J Nutr Health Aging. Jun 2015, DOI: 10.1007/s12603-015-0554-4