Larry Lands, MD, PhD
Cystic fibrosis (CF) • asthma • immune modulation • physical activity • translational research
My research focuses on children with lung diseases, such as asthma and cystic fibrosis, that have excessive inflammation in their lungs. This often limits their ability to be physically active. I study how to calm down lung inflammation, boost immune defences, and improve physical performance. In our laboratory we are attempting to increase natural immunity to respiratory viral infections, to prevent people with chronic lung disease from becoming sicker when they catch a cold. The immune-boosting abilities of vitamin D are also being examined, as are the immune and performance enhancing properties of our novel whey protein supplement. And to help patients benefit from an active lifestyle, we are studying a new motivational program to encourage physical activity in patients with cystic fibrosis.
Dauletbaev N, Lam J, Eklove D, Lands LC. Ibuprofen modulates NF-κB but not IL-8 in cystic fibrosis respiratory epithelial cells. Respiration 79:234-242, 2010.
83. Lands LC, Iskandar M (S), Beaudoin N, Meehan B, Dauletbaev N, Berthiaume Y. Dietary supplementation with pressurized whey in patients with cystic fibrosis. J of Medicinal Foods 13:77-82, 2010.
Saiman L, Anstead M, Mayer-Hamblette N, Lands LC, Kloster M, Hocevar-Trnka J, Goss CH, Rose LM, Burns JL, Marshall BC, Ratjen F. Effect of Azithromycin on Pulmonary Function in Patients with Cystic Fibrosis Uninfected with Pseudomonas aeruginosa: A Randomized Controlled Trial . JAMA 303(17):1707-1705, 2010.
Dauletbaev N, Eklove D, Mawji N, Iskandar M, Di Marco S, Gallouzi I, Lands LC. Both MKP-1 dependent and independent inhibition of p38 MAPK are required for efficient pharmacological down-regulation of IL-8. JBC 286 (18):15998-16007, 2011.
McIlwaine MP, Alarie N, Davidson GF, Lands LC, Ratjen F, Milner R, Owen B, Agnew JL. Long-term multi-centre randomised controlled study of high frequency chest wall oscillation versus positive expiratory pressure mask in cystic fibrosis. Thorax 68:746-751, 2013.