Nancy Low, MD, MSc
Research Institute of the McGill University Health Centre
Regular Member Health Outcomes Neurosciences
McGill University Health Centre (MUHC)
Staff Psychiatrist, Mood Disorders Program
My research focuses on families with mood and anxiety disorders to understand how having a family history puts someone at risk for a psychiatric disorder. I study the role that familial environments (e.g. childhood adversity) and genetic backgrounds may play. I also study the impact of environmental risk factors for mood disorders, such as stressful life events. Finally, I study risk factors that may be modifiable by treatment or eductation, such as the way people cope, their patterns of thinking, their social support and their level of physical activity. I use study subjects that may be from clinics as well those in the community at large.
- familial aggregation of psychiatric disorders
- population-based and cohort studies
- phenotypic heterogeneity in mood disorders
- modifiers of familial transmission of mood disorders (e.g. comorbidity with medical disorders)
- environmental determinants: stressful life events, childhood adversity
- modifiable risk factors: coping, social support, cognitive style, physical activity
mood disorders, bipolar, depression, anxiety, family, stressful life events, childhood adversity, longitudinal, cohort, population-based
Low NC, Dugas E, Constantin E, Karp I, Rodriguez D, O'Loughlin J.The association between parental history of diagnosed mood/anxiety disorders and psychiatric symptoms and disorders in young adult offspring. BMC Psychiatry. 2012 Nov 5;12:188. doi: 10.1186/1471-244X-12-188.
Low NC, Dugas E, O'Loughlin E, Rodriguez D, Contreras G, Chaiton M, O'Loughlin J.Common stressful life events and difficulties are associated with mental health symptoms and substance use in young adolescents. BMC Psychiatry. 2012 Aug 17;12:116. doi: 10.1186/1471-244X-12-116.
Dugas E, Low NC, Rodriguez D, Burrows S, Contreras G, Chaiton M, O'Loughlin J. Early predictors of suicidal ideation in young adults. Can J Psychiatry. 2012 Jul;57(7):429-36.
Knappe S, Lieb R, Beesdo K, Fehm L, Low NC, Gloster AT, Wittchen HU. The role of parental psychopathology and family environment for social phobia in the first three decades of life. Depress Anxiety. 2009;26(4):363-70. doi: 10.1002/da.20527.
Low NC, Cui L, Merikangas KR. Community versus clinic sampling: effect on the familial aggregation of anxiety disorders. Biol Psychiatry. 2008 May 1;63(9):884-90. Epub 2007 Oct 22.