Simon Wing, MD
ubiquitin • muscle wasting • spermatogenesis • cachexia • diabetes
My research focuses on understanding why people lose muscle mass and muscle protein when they become ill. In addition I also study the role of degradation of cell proteins in sperm development and function. In this way, we can develop drugs that can prevent muscle wasting or that can be used for male contraception. This will also help identify new approaches to the treatment of male infertility.
Bédard N, Jammoul S, Moore T, Wykes L, Hallauer PL, Hastings KEM, Stretch C, Baracos V, Chevalier S, Plourde M, Coyne E, Wing SS. Inactivation of the USP19 Deubiquitinating Enzyme Protects Against Muscle Wasting Caused by Glucocorticoids or Denervation. FASEB J 2015; in press PMID: 26048142.
Wiles B, Miao M, Coyne E, Larose L, Cybulsky AV, and Wing SS. USP19 deubiquitinating enzyme inhibits muscle cell differentiation by suppressing unfolded-protein response signaling. Mol. Biol. Cell 2015, 26: 913-923 PMID: 25568336
Yang Y, Duguay D, Bedard N, Rachalski A, Baquirin G, Na CH, Fahrenkrug J, Storch F, Peng J, Wing SS and Cermakian N. Regulation of behavioural circadian rhythms and clock protein PER1 by the deubiquitinating enzyme USP2. Biology Open 2012, 1: 789-801, doi: 10.1242/bio.20121990 PMID: 23213472.
Bedard N, Yang Y, Gregory M, Cyr DG, Suzuki J, Yu X, Clarke H, Chian RC, Hermo L, O'Flaherty C, Smith CE and Wing SS. Mice Lacking the USP2 Deubiquitinating Enzyme have Severe Male Sub-Fertility Associated with Defects in Fertilization and Sperm Motility. Biol. Repro. 2011, 85: 594-604. PMID: 21543767.
Liu Z, Oughtred R, and Wing SS. Characterization of E3-Histone, a novel testis ubiquitin protein ligase which ubiquitinates histones. Mol. Cell. Biol. 2005; 25: 2819-2831 PMID: 15767685.