Andrey Cybulsky, MD
cell injury • complement • glomerulonephritis • phospholipases • protein kinases
My research focuses on diseases of the renal glomerulus (the filtering unit of the kidney), especially those initiated by immunological processes ("glomerulonephritis"). These diseases account for approximately half of the causes of chronic kidney disease in Canada. Fundamental research into the disordered immune mechanisms that lead to glomerulonephritis is essential to the understanding of these diseases, an understanding that will ultimately lead to therapy and perhaps prevention. My research is directed at understanding pathophysiological changes in kidney cells in immunological disorders and inflammation. Work in the lab focuses on signals in cells that are involved in the mediation of cell injury. There are three specific research themes, including: complement C5b-9 signaling and mechanisms of injury, extracellular support structures and cell skeleton as determinants of signaling responses, and regulation of intracellular proteins that mediate signals in the kidney.
Delarosa S, Guillemette J, Papillon J, Han YS, Kristof AS, Cybulsky AV. Activity of the Ste20-like kinase, SLK, is enhanced by homodimerization. Am J Physiol. 2011, 301, F554-F564. PMID: 21677149.
Luhovy AY, Jaberi A, Papillon J, Guillemette J, Cybulsky AV. Regulation of the Ste20-like kinase, SLK: involvement of activation segment phosphorylation. J Biol Chem. 2012, 287, 5446-5458. PMID: 22203681.
Kitzler TM, Papillon J, Guillemette J, Wing SS, Cybulsky AV. Complement modulates the function of the ubiquitin-proteasome system and endoplasmic reticulum-associated degradation in glomerular epithelial cells. Biochim Biophys Acta Mol Cell Res. 2012, 1823, 1007-1016. PMID: 22426620.
Elimam H, Papillon J, Takano T, Cybulsky AV. Complement-mediated activation of calcium-independent phospholipase A2γ: role of protein kinases and phosphorylation. J Biol Chem. 2013, 288, 3871-3885. PMID: 23258543.
Drozdova T, Papillon J, Cybulsky AV. Nephrin missense mutations: induction of endoplasmic reticulum stress and cell surface rescue by reduction of chaperone interactions. Physiol Rep. 2013, 1(4), e00086. PMID: 24303155.