Donald van Meyel, MD
morphogenesis • axon guidance • dendrite development • hedgehog signaling • neuron-glial interactions
My research focuses on neurons and glial cells, two major cell types in the human central nervous system (CNS), and interactions between them are vital for the CNS to develop and function properly. In addition, signaling between neurons requires the establishment of precise and complex intercellular connections through the patterned development of axons and dendrites. Research themes in my lab focus on: 1) The importance of neuron-glial interactions during development and how perturbations of these processes can contribute to neurological diseases. 2) The patterned growth and guidance of axons and dendrites and how improved understanding of the underlying mechanisms can be used to promote repair in the injured or diseased CNS. 3) Molecular mechanisms of the Hedgehog (Hh) signaling pathway, which is vital for nervous tissue development and is misregulated in pediatric brain tumors.
Ferreira, T, Blackman A.V., Oyrer J, Chung, A.J., Jayabal, S., Watt, A.J., Sjöström, PJ, van Meyel, D.J. Sholl-based morphometry directly from bitmap images of neuronal arbors. (2014) Nature Methods 11(10):982-4.
Camp, D., He, B.H., Charron, F., van Meyel, D.J. Reception and sequestration of the Hedgehog signal: identification of Ihog/Boi-dependent and -independent roles for Ptc. (2014) Development 141(20):3879-88.
Ferreira, T., Ou, Y., Li. S., Giniger, E., and van Meyel, D.J. Dendrite architecture organized by transcriptional control of the F-actin nucleator Spire. (2014) Development 141(3):650-660. PMID: 24449841.
Stacey, S.M., Muraro, N.I., Peco, E., Labbé, A., Thomas, Graham B., Baines, R.A. and van Meyel, D.J. Drosophila glial glutamate transporter Eaat1 is regulated by Fringe-mediated Notch signaling and is essential for larval locomotion. (2010) Journal of Neuroscience 30: 14446-57. PMID: 20980602.
Camp, D., Currie, K., Labbé, A., van Meyel, D.J.*, and Charron, F.* Ihog and Boi are essential for Hedgehog signaling in Drosophila. (2010) Neural Development 5:28. *Corresponding authors. PMID: 21044292.