Jean-Jacques Lebrun, MSc, PhD
Research Institute of the McGill University Health Centre
Regular Member Cancer
McGill University Health Centre (MUHC)
Associate Dean, Graduate & Postdoctoral Studies
My research focuses on investigating the role and mechanism of action of the transforming growth factor-β (TGFβ) in the regulation of tumor formation and cancer progression, with a long term goal of developing novel therapies against metastatic cancer. The various research projects that I developed in my laboratory are based on the dual role of this growth factor in cancer. On one hand TGFB exerts tumor suppressive effects in normal cells and in early carcinomas whereas in advanced cancer TGFβ has pro-migratory and pro-invasive functions. With this information, we have developed two lines of research. The first is defining the tumor suppressive role of TGFβ and how this growth factor inhibits cell proliferation, induces apoptosis, and prevents cell immortalization in normal cells and early carcinomas. The second is defining the pro-metastatic effect of this cytokine in invasive cancers, focusing on breast cancer, with the goal of designing novel anti-TGFβ signaling therapies against cancer.
- tumor suppression (cell cycle arrest, apoptosis, cell immortalization), TGFβ/Smad signaling, Cancer stem cell biology, microRNAs in cancer, Melanoma research
- TGFβ/Smad signaling
- cancer stem cell biology
- microRNAs in cancer
- melanoma research
- breast cancer metastasis
TGFβ, Smad signaling, tumor suppression, breast cancer metastasis, melanoma research, cell growth arrest, apoptosis, cell immortalization, cell migration, cell invasion
Dai M, AlOdaini A, Arakelian A, Rabbani S, Ali S, Lebrun JJ (2012) A novel function for p21 as a critical regulator of TGFβ mediated breast cancer metastasis. Breast Cancer Res, 2012 Sep 20;14(5):R127.
Korah J, Falah N, Lacerte A, Lebrun JJ (2012). A transcriptionally active pRb-E2F1-P/CAF signaling pathway is central to TGFβ-mediated apoptosis, Cell Death and Disease, Nature Publishing Group, Vol 3. Pp 407
Humbert L and Lebrun JJ (2013) TGF-beta inhibits human cutaneous melanoma cell migration and invasion through regulation of the plasminogen activator system Cell Signaling, Vol 25(2), 490-500
Fils-Aime N, Dai M, Guo J, Kahramangil B, Neel JC, Lebrun JJ. (2013). Micro-RNA-584 and PHACTR1: New Signaling Route Through Which Transforming Growth Factor-Beta Mediates the Migration and Actin Dynamics of Breast Cancer Cells. J Biol Chem 2013 Mar 11.
Neel JC, Lebrun JJ. (2013). Activin and TGFβ regulate expression of the microRNA-181 family to promote cell migration and invasion in breast cancer cells. Cell Signaling, 2013 Mar 22;25(7):1556-1566