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Peter Metrakos, MD

Research Institute of the McGill University Health Centre

Regular Member
Cancer
Infection and immunity


McGill University Health Centre (MUHC)

Director of the Multi-Organ Transplant Program and Director of Hepatopancreatobiliary Surgery


McGill University

Associate Professor of Surgery, Pathology and Anatomy and Cell Biology


Research Interest


My research focuses on liver physiology, pathology and molecular signatures. Non-alcoholic fatty liver disease (NAFLD) is now the leading cause of liver disease in North America and can lead to Type II diabetes, liver cirrhosis (requiring liver transplantation), liver cancer (hepatocellular cancer, ) and increase the probability of other types of cancer spreading to the liver(liver metastasis). With the help of our human tissue bank and technologies such as proteomics and genomics, we hope to find new therapies for these diseases.

Research Foci


  • colorectal cancer liver metastases
  • neuroendocrine tumours
  • hepatocellular carcinoma
  • mTOR targeted therapies
  • liver ischemia/reperfusion injury
  • molecular mechanisms of NAFLD/NASH progression

Keywords


liver metastasis, liver ischemia/reperfusion injury, non-alcoholic liver disease, hepatocellullar carcinoma, neuroendocrine tumors, proetomics, tissue banking

Selected Publications


Click on Pubmed to see my current publications list

  • Boutros T, Nantel A, Emadali A, Tzimas G, Conzen S, Chevet E, Metrakos P. The map kinase phosphatase-1 mkp-1/dusp1 is a regulator of human liver response to transplantation. Am J Transplant. 2008 Dec;8(12):2558-68.

  • Alain T, Morita M, Fonseca BD, Yanagiya A, Siddiqui N, Bhat M, Zammit D, Marcus V, Metrakos P, Voyer LA, Gandin V, Liu Y, Topisirovic I, Sonenberg N. eIF4E/4E-BP Ratio Predicts the Efficacy of mTOR Targeted Therapies. Cancer Res. 2012 Dec 15;72(24):6468-6476

  • Raymond E, Dahan L, Raoul JL, Bang YJ, Borbath I, Lombard-Bohas C, Valle J, Metrakos P, Smith D, Vinik A, Chen JS, Hörsch D, Hammel P, Wiedenmann B, Van Cutsem E, Patyna S, Lu DR, Blanckmeister C, Chao R, Ruszniewski P. Sunitinib malate for the treatment of pancreatic neuroendocrine tumors. N Engl J Med. 2011 Feb 10;364(6):501-13

  • Jamal MH, Hassanain M, Chaudhury P, Tran TT, Wong S, Yousef Y, Jozaghi Y, Salman A, Jabbour S, Simoneau E, Al-Abbad S, Al-Jiffry M, Arena G, Kavan P, Metrakos P. Staged hepatectomy for bilobar colorectal hepatic metastases. HPB (Oxford). 2012 Nov;14(11):782-9

  • Histology-driven data mining of lipid signatures from multiple imaging mass spectrometry analyses: application to human colorectal cancer liver metastasis biopsies. Thomas A, Patterson NH, Marcinkiewicz MM, Lazaris A, Metrakos P, Chaurand P. Anal Chem. 2013 Mar 5;85(5):2860-6