YEAR IN REVIEW: Infectious Diseases and Immunity in Global Health Program (IDIGH) - Research Institute of the McGill University Health Centre

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null YEAR IN REVIEW: Infectious Diseases and Immunity in Global Health Program (IDIGH)

RESEARCH HIGHLIGHTS

Drs. Marina Klein, Matthew Cheng and Cedric Yansouni — **Drs. Marina Klein, Matthew Cheng** and Cedric Yansouni

Montréal sans HépC

Dr. Marina Klein co-led initiative to make Montreal the first city in North America to eliminate hepatitis C, partnered with CR-CHUM and Lady Davis Research Institute.

Community-oriented approach involves frontline workers.

Sepsis: Test before starting treatment

Drs. Matthew Cheng and Cédric Yansouni, with UBC and Harvard Medical School collaborators, confirmed the importance of obtaining blood cultures before giving antibiotics to septic patients.

Increases likelihood of identifying a pathogen and providing targeted treatment (Annals of Internal Medicine).

New family of enzymes identified in fungal infections

Dr. Don Sheppard with Lynne Howell (PhD), University of Toronto, identified an enzyme critical for biofilm formation in the fungus Aspergillus fumigatus.

Co-first author (Nature Communications): postdoc François Le Mauff (PhD).

Dr. Don Sheppard’s lab — **Dr. Don Sheppard’s** lab

SELECTED PUBLICATIONS

Ákos Iliás, Kata Judit Szántó, Lóránt Gönczi, Zsuzsanna Kürti, Petra Anna Golovics, Klaudia Farkas, Eszter Schäfer, Zoltán Szepes, Balázs Szalay, Áron Vincze, Tamás Szamosi, Tamás Molnár, Péter László Lakatos. Outcomes of Patients With Inflammatory Bowel Diseases Switched From Maintenance Therapy With a Biosimilar to Remicade. Clinical Gastroenterology and Hepatology 17(12):2506-2513.e2, 2019.

Amine Benmassaoud, Roy Nitulescu, Thomas P.I. Pembroke, Alex S. Halme, Peter Maged Ghali, Marc Deschênes, Philip Wong, Marina Barbara Klein, Giada Sebastiani. Liver-related Events in Human Immunodeficiency Virus-infected Persons with Occult Cirrhosis. Clinical Infectious Diseases 69(8):1422-1430, 2019.

David R. Boulware, Matthew F. Pullen, Ananta S. Bangdiwala, Katelyn Pastick, Sarah Lofgren, Elizabeth C. Okafor, Caleb Skipper, Alanna A. Nascene, Melanie R. Nicol, Mahsa Abassi, Nicole W. Engen, Matthew P. Cheng, Derek LaBar, Sylvain A. Lother, Lauren J. MacKenzie, Glen Drobot, Nicole Marten, Ryan Zarychanski, Lauren E. Kelly, Ilan S. Schwartz, Emily G. McDonald, Radha Rajasingham, Todd C. Lee, Kathy H. Hullsiek. (2020). A Randomized Trial of Hydroxychloroquine as Postexposure Prophylaxis for Covid-19. The New England journal of medicine, 383: 517-525, 2020.

Natalie C. Bamford, François Le Mauff, Jaime Van Loon, Hanna Ostapska, Brendan D. Snarr, Yongzhen Zhang, Elena N. Kitova, John S. Klassen, Jeroen D. C. Codée, Donald C. Sheppard, P. Lynne Howell. (2020). Structural and biochemical characterization of the exopolysaccharide deacetylase Agd3 required for Aspergillus fumigatus biofilm formation. Nature Communications 11: 2450, 2020.

Shannon C. Duffy, Sreenidhi Srinivasan, Megan A. Schilling, Tod Stuber, Sarah N. Danchuk, Joy S. Michael, Manigandan Venkatesan, Nitish Bansal, Sushila Maan, Naresh Jindal, Deepika Chaudhary, Premanshu Dandapat, Robab Katani, Shubhada Chothe, Maroudam Veerasami, Suelee Robbe-Austerman, Nicholas Juleff, Vivek Kapur, Marcel A. Behr. Reconsidering Mycobacterium bovis as a proxy for zoonotic tuberculosis: a molecular epidemiological surveillance study. The Lancet Microbe 1(2):e66-e73, 2020.

Vinicius M. Fava, Yong Zhong Xu, Guillaume Lettre, Nguyen Van Thuc, Marianna Orlova, Vu Hong Thai, Shao Tao, Nathalie Croteau, Mohamed A. Eldeeb, Emma J. MacDougall, Geison Cambri, Ramanuj Lahiri, Linda Adams, Edward A. Fon, Jean-François Trempe, Aurélie Cobat, Alexandre Alcaïs, Laurent Abel, Erwin Schurr. Pleiotropic effects for Parkin and LRRK2 in leprosy type-1 reactions and Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. 116(31): 15616-15624, 2019.

Vikram Mehraj, Rayoun Ramendra, Stéphane Isnard, Franck P. Dupuy, Rosalie Ponte, Jun Chen, Ido P. Kema, Mohammad Ali Jenabian, Cecilia T. Costiniuk, Bertrand Lebouché, Réjean Thomas, Pierre Côté, Roger P. LeBlanc, Jean Guy Baril, Madéleine Durand, Carl Chartrand-Lefebvre, Cécile L. Tremblay, Petronela Ancuta, Nicole Flore Bernard, Donald C. Sheppard, Jean Pierre G. Routy. Circulating (1→3)-β-D-glucan is associated with immune activation during human immunodeficiency virus infection. Clinical Infectious Diseases 70(2):232- 242, 2020.

Yujian H. Yang, Roman Istomine, Fernando Alvarez, Tho-Alfakar Al-Aubodah, Xiangqun Shi, Tomoko Takano, Angela M. Thornton, Ethan M. Shevach, Ji Zhang, Ciriaco A. Piccirillo. Salt Sensing by Serum/Glucocorticoid-Regulated Kinase 1 Promotes Th17-like Inflammatory Adaptation of Foxp3+ Regulatory T Cells. Cell Reports 30(5):1515-1529.e4, 2020.