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RI-MUHC ANNUAL REPORT 2020

null YEAR IN REVIEW: Translational Research in Respiratory Diseases Program (RESP)

RESEARCH HIGHLIGHTS

Changing the way latent tuberculosis is treated

New study shows that a rifampin regimen is not only safer, shorter, and as effective as standard isoniazid treatment, but also cheaper.

Dr. Dick Menzies is last study author (Ann Intern Med.).

Why some non-smokers get COPD

Dysanapsis, a developmental mismatch between airway and lung size, was proved a yet stronger risk factor for chronic obstructive pulmonary disease (COPD) than smoking.

Dr. Benjamin Smith is first study author (JAMA).

Understanding the hallmarks of asthma

Researchers demonstrated that intrapulmonary airway smooth muscle is hypercontractile in asthma and identified several proteins that could be targeted for treatment.

Anne-Marie Lauzon (PhD) is last study author (Eur Respir J.).

Dick Menzies, MD, Benjamin Smith, MD, and Anne-Marie Lauzon, PhD
Dick Menzies, MD, Benjamin Smith, MD, and Anne-Marie Lauzon, PhD

SELECTED PUBLICATIONS

Benoit Allard, Alice Panariti, Erwan Pernet, Jeffrey Downey, Satoshi Ano, Marieme Dembele, Emily M. Nakada, Utako Fujii, Toby K. McGovern, William S. Powell, Maziar Divangahi, James G. Martin. Tolerogenic signaling of alveolar macrophages induces lung adaptation to oxidative injury. Journal of Allergy and Clinical Immunology 144(4):945-961.e9, 2019.

Deborah Assayag, Julie Morisset, Kerri A. Johannson, Athol Umfrey Wells, Simon L.F. Walsh. Patient gender bias on the diagnosis of idiopathic pulmonary fibrosis. Thorax 75(5):407-412, 2020.

Jonathon R. Campbell, Anete Trajman, Victoria J. Cook, James Cameron Johnston, Mênonli Adjobimey, Rovina Ruslami, Lisa Eisenbeis, Federica Fregonese, Chantal Valiquette, Andrea L. Benedetti, Dick Menzies. Adverse events in adults with latent tuberculosis infection receiving daily rifampicin or isoniazid: post-hoc safety analysis of two randomised controlled trials. The Lancet Infectious Diseases 20(3):318- 329, 2020.

Nikolay Moroz, Karen Maes, Jean Philippe Leduc-Gaudet, Peter Goldberg, Basil J. Petrof, Dominique Mayaki, Theodoros Vassilakopoulos, Dilson E. Rassier, Ghislaine N. Gayan-Ramirez, Sabah N.A. Hussain. Oxidants Regulated Diaphragm Proteolysis during Mechanical Ventilation in Rats. Anesthesiology 131(3): 605-618, 2019.

Qiuji Ye, Shishir Chourey, Chintam Nagendra Reddy, Rui Wang, Chantal Cossette, Sylvie Gravel, Irina Slobodchikova, Dajana Vuckovic, Joshua Rokach, William S. Powell. Novel highly potent OXE receptor antagonists with prolonged plasma lifetimes that are converted to active metabolites in vivo in monkeys. British Journal of Pharmacology 177(2): 388-401, 2020.

Syed Abidi, Jay Achar, Mourtala Mohamed Assao-Neino, Didi Bang, Andrea L. Benedetti, Sarah Kathleen Brode, Jonathon R. Campbell, Esther Carrillo Casas, Francesca M. Conradie, Gunta Dravniece, Philipp A. Du Cros, Dennis Falzon, Ernesto Jaramillo, Christopher Kuaban, Zhiyi Lan, Christoph G. Lange, Peizhi Li, Mavluda Makhmudova, Aung Kya Jai Maug, Dick Menzies, Giovanni Battista Migliori, Ann C. Miller, Bakyt B. Myrzaliev, Norbert O. Ndjeka, Juergen Noeske, Nargiza N. Parpieva, Alberto Piubello, Valérie Schwœbel, Welile Sikhondze, Rupak Singla, Mahamadou Bassirou Souleymane, Arnaud Trébucq, Armand van Deun, Kerri Viney, Karin Weyer, Betty Jingxuan Zhang, Faiz Ahmad Ahmad Khan. Standardised shorter regimens versus individualised longer regimens for rifampin- or multidrug-resistant. European Respiratory Journal 55(3):1901467, 2020.

Tania Janaudis-Ferreira, Sunita Mathur, Robin Donna Deliva, Nancy Howes, Catherine Patterson, Agnès Räkel, Stephanie So, Lisa M. Wickerson, Michel White, Yaron Avitzur, Olwyn Johnston, Norine Heywood, Sunita K.S. Singh, Sandra Holdsworth. Exercise for Solid Organ Transplant Candidates and Recipients: A Joint Position Statement of the Canadian Society of Transplantation and CAN-RESTORE. Transplantation 103(9):e220-e238, 2019.

Wissam Shalish, Lara J. Kanbar, Lajos B. Kovács, Sanjay Chawla, Martin Keszler, Smita Rao, Samantha Latremouille, Doina Precup, Karen A. Brown, Robert E. Kearney, Guilherme Mendes Sant'Anna. Assessment of Extubation Readiness Using Spontaneous Breathing Trials in Extremely Preterm Neonates. JAMA Pediatrics 174(2):178-185, 2020.

Translational Research in Respiratory Diseases Program (RESP)

rimuhc.ca/RESP