The Cardiovascular Health across the Lifespan Program (CHAL) includes fundamental, clinical and evaluative research platforms. Basic research in this program focuses on the study of biomarkers, histopathology, genetics, translational genomics and genetic epidemiology. Biomedical and clinical research is conducted in the domains of biodesign, health technology, regenerative medicine and information technology, with observational cardiovascular studies and clinical trials completed or underway. CHAL investigators with expertise in epidemiology conduct population health, outcomes and health services research.
The CHAL program is primarily located at the Glen site of the Research Institute of the McGill University Health Centre (RI-MUHC), with several of its members at the Montreal General Hospital site. CHAL investigators perform research at the Centre for Translational Biology, the Centre for Innovative Medicine and the Centre for Health Outcomes Research at the RI-MUHC.
Dr. Ariane Marelli is Professor of Medicine at McGill University and is the Associate Director for Research and Academic Affairs for Cardiology at the McGill University Health Centre. She is an associate member of the Department of Epidemiology, Biostatistics and Occupational Health. Her research interests involve the impact of the changing epidemiology of congenital heart disease on health services delivery, quality and policy. Her research tools have included large administrative databases and electronic health records. She created and manages a population-based congenital heart disease database that covers over 100,000 patients with congenital heart disease from birth to old age in Quebec, from 1983 to 2010. Along with Dr. Jack Lewin, CEO of the American College of Cardiology, she was a first recipient of the 2011 Heart Heroes Award from the Adult Congenital Heart Association in recognition of "visionary leadership in epidemiology, quality of care and health IT for congenital heart disease patients." Her research is supported by the Canadian Institutes of Health Research, the Heart and Stroke Foundation of Canada and the Fonds de recherche du Québec−Santé (FRQS). She is a clinical research scholar of the FRQS.
Dr. Stella S. Daskalopoulou is a tenured Associate Professor of Medicine at McGill University. She established and directs the Vascular Health Unit at the McGill University Health Centre, where she conducts research projects on vascular structure and function, including the identification of novel pathways of atherosclerotic plaque instability, image analysis of atherosclerosis plaque composition, and arteriosclerosis, with special interest in arterial stiffness and hemodynamics in subjects with cardiovascular risk factors, such as hypertension, smoking, diabetes, dyslipidemia, and pre-eclampsia. Dr. Daskalopoulou's research has led to over 100 peer-reviewed publications. She is a member of the central review committee of the Canadian Hypertension Education Program (CHEP), the Executive Committee of the Société des Sciences Vasculaires du Québec, and the North America Artery Society. Dr. Daskalopoulou has received several personal awards, including the Hypertension Canada New Investigator Award, the Young Researcher Award of Excellence from the Heart and Stroke Foundation of Quebec, the Canadian Foundation for Women's Health Research, the Bourse Fonds de recherche du Québec−Santé (FRQS) ─La Société Québécoise d'Hypertension Artérielle Jacques-de-Champlain, and the Canadian Society of Internal Medicine New Investigator award. Dr. Daskalopoulou holds several research grants from the Canadian Institutes of Health Research, FRQS, Heart and Stroke Foundation of Canada and Canada Foundation for Innovation Leaders Opportunity Fund, amongst others. She is a clinical research scholar of the FRQS.
Dr. Dominique J. Favreau obtained his doctorate in immunology and virology from the Institut national de la recherche scientifique with awards in leadership. He brings to the CHAL Program more than ten years of experience in project and financial management, administration and communications, earned in the diverse environments of academia, industry and hospitals. His work as a technology transfer advisor at the CHU-Ste-Justine and Hôpital Maisonneuve-Rosemont has led him to fully appreciate the realities that challenge clinicians in a research environment.