null Erwin Schurr, PhD
tuberculosis • leprosy • complex traits • transcriptomics • systems biology
My research focuses on the identification and evaluation of host genetic factors in tuberculosis and leprosy. We are working with partner groups in endemic countries for those diseases and are applying modern concepts of genetics, genomics and sytems biology to our analyses.
V.M. Fava, Y.Z. Xu, G. Lettre, N.V. Thuc, M. Orlova, V.H. Thai, G. Cambri, S. Tao, L. Ramanuj, L. Adams, A. Cobat, A. Alcaïs, L. Abel, E. Schurr Pleiotropic effects for Parkin and LRRK2 in leprosy reversal reactions and Parkinson’s disease Proc. Natl. Acad. Sci. USA 116:15616-15624, 2019.
M. Dallmann-Sauer, V.M. Fava, C. Gzara, M. Orlova, N.V. Thuc, V.H. Thai, A. Alcaïs, L. Abel, A. Cobat, E. Schurr The complex pattern of genetic associations of leprosy with class I and class II HLA alleles can be reduced to four amino acid positions. PLoS Pathog, 16(8):e1008818, 2020.
J. Quistrebert, M. Orlova, G. Kerner, L.T. Ton, N.T. Luong, N.T. Danh, F. Jabot-Hanin, Y. Seeleuthner, J. Bustamante, S. Boisson-Dupuis, N.T. Huong, N.N. Ba, J-L Casanova, C. Delacourt, E.G. Hoal, A. Alcaïs, V.H. Thai, L. The Thành, L. Abel, E. Schurr, A. Cobat Genome-wide association study of resistance to Mycobacterium tuberculosis infection identifies a locus at 10q26.2 in three distinct populations PLoS Genet 17:1-18, 2021.
W. Correa-Macedo, V.M. Fava, M. Orlova, P. Cassart, R Olivenstein, J. Sanz, A. Dumaine, R.H.M. Sindeaux, V. Yotova, A. Pacis, J. Girouard, B. Kalsdorf, C. Lange, J.-P. Routy, L.B. Barreiro, E. Schurr, Epigenetic impairment and blunted transcriptional response to Mycobacterium tuberculosis of alveolar macrophages from persons living with HIV, J Clin Invest, Sep 2:148013. doi: 10.1172/JCI148013, 2021.
V.M. Fava, M. Bourgey, P.M. Nawarathna, M. Orlova, Pauline Cassart, M.P. Cheng, G. Bourque, E. Schurr, D. Langlais A system biology approach identifies candidate drugs to reduce mortality in severely ill COVID-19 patients, Sci Adv, in press.