null Matthias Friedrich, MD, FESC, FACC
Cardiovascular magnetic resonance • myocardial ischemia • coronary heart disease • acute myocardial infarction • myocarditis
The research activities of the Cardiovascular Magnetic Resonance (CMR) Research Centre at the McGill University Health Centre focus on novel techniques that permit the optimization and simplification of clinical CMR protocols that require minimal interaction and reduce the need for contrast agents or stress protocols. This includes the application of novel CMR image reconstruction techniques, machine learning, automated scanning, and the validation of novel imaging biomarkers in clinical studies. Several current projects explore new options for assessing coronary vascular function, using breathing manoeuvres instead of traditional pharmacological vasodilators or stress protocols as vasoactive triggers. The CMR Research Team aims for new knowledge that can significantly change diagnostic cardiology. The team has access to two clinical MRI scanners (Siemens Skyra 3.0T, GE Artist 1.5T) and full-time access to a dedicated MRI system (GE Premier 3.0T) for CMR research. The most significant support for the research program comes from the Family Courtois Foundation through the McGill University Health Centre Foundation. There is a close collaboration with invasive and non-invasive cardiology, cardiac surgery, and radiology teams. The team also has active collaborations with other hospitals in Montreal, as well as with other academic centres in Canada and worldwide, including cohort research with the Canadian Alliance for Healthy Hearts and Minds.
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Anand SS, Tu JV, Desai D Anand SS, Tu JV, Desai D, Awadalla P, Robson P, Jacquemon S, Dummer T, Le N, Parker L, Poirier P, Teo T, Lear SA, Yusuf S, Tardif JC, Marcotte F, Busseuil D, Després JP, Black SE, Kirpalani A, Parraga G, Noseworthy MD, Dick A, Leipsic J, Kelton D, Vena J, Thomas M, Schulze KM, Moody AR, Larose E, Smith EE, and Friedrich MG. Cardiovascular Risk Scoring and Magnetic Resonance Imaging Detected Subclinical Cerebrovascular Disease. Eur Heart J: CV Imaging, in press.
Hawkins S, Guensch DP, Friedrich MG, Vinco G, Nadeshalingham G, White M, Mongeon FP, Hillier E, Teixeira T, Flewitt JA, Eberle B, Fischer K. Hyperventilation-induced heart rate response as a potential marker for cardiovascular disease. Sci Rep 2019;9(1):17887.
Luu J, Schmidt A, Flewitt J, Mikami Y, ter Keurs H, Friedrich MG. Cardiovascular Risk is Associated with a Transmural Gradient of Myocardial Oxygenation During Adenosine Infusion. Eur Heart J: (2019) 20, 1287–1295.
Roubille F, Fischer K, Guensch DP, Tardif J-C, Friedrich MG. Impact of hyperventilation and apnea on myocardial oxygenation in patients with obstructive sleep apnea - An oxygenation-sensitive CMR study. Journal of Cardiology. 2017;69:489–494.
Fischer K, Guensch D, Shie N, Lebel J, Friedrich MG. Breathing Maneuvers as a Vasoactive Stimulus for Detecting Inducible Myocardial Ischemia - an Experimental Cardiovascular Magnetic Resonance Study. PLoS ONE 2016;11:e0164524.